TABLE 11

In vitro characterization of genetic polymorphisms in NTCP

In vitro function was assessed using prototypical substrates for NTCP (taurocholate and cholate). Data are from Ho et al. (2004).

Nucleotide ChangeAmino Acid ChangeIn Vitro FunctionProtein Expression/Localization
SLC10A1NTCP
    T668C    I223TIntracellular
    C800T    S267FNormal
    T836C    I279TNormal
    A940G    K314ENormal
  • ↓, reduced function.