TABLE 2

Subcellular localization of uptake OATP/Oatp transporters in various species

For each transporter, the apical or basolateral localization in a particular tissue and/or species is provided. Species included rat (R), mouse (M), human (H), and bovine (B). Detailed information regarding particular cellular populations or regions of the tissue are provided for some transporter isoforms.

Cellular LocalizationTissueSpeciesCell TypesReferences
Oatp1a1
    BasolateralLiverRHepatocytesEckhardt et al., 1999
    ApicalKidneyRProximal tubule cellsBergwerk et al., 1996
    ApicalChoroid plexusREpithelial cellsAngeletti et al., 1997
Oatp1a4
    BasolateralLiverRHepatocytes (midzonal to centrilobular)Kakyo et al., 1999; Reichel et al., 1999
    BasolateralChoroid plexusREpithelial cellsGao et al., 1999
    BasolateralBrainRCapillary endothelial cellsRoberts et al., 2008
    ApicalEyeRRetinal pigment epitheliumGao et al., 2002; Ito et al., 2002
Oatp1a5
    ApicalChoroid plexusMEpithelial cellsOhtsuki et al., 2004b
    ApicalBrainMCapillary endothelial cellsOhtsuki et al., 2004b
    ApicalJejunumREnterocytesWalters et al., 2000
    N.D.EyeRNerve fiber, ganglion cellsIto et al., 2002
Oatp1b2
    BasolateralLiverRHepatocytesCattori et al., 2001
Oatp2a1
    N.D.KidneyRGlomeruli, endothelial cells, collecting ductsBao et al., 2002
Oatp2b1
    BasolateralBrainRCapillary endothelial cellsRoberts et al., 2008
    ApicalChoroid PlexusREpithelial cellsRoberts et al., 2008
Oatp3a1
    N.D.HeartRAorta endothelial cellsAdachi et al., 2003
    N.D.LungRAlveolar epithelial cellsAdachi et al., 2003
    N.D.TracheaRMucosal epitheliumAdachi et al., 2003
    N.D.TestesRSpermatozoa tailsAdachi et al., 2003
    N.D.OvaryROocytes and smooth muscle cellsAdachi et al., 2003
    N.D.UterusRGlandula uterine epithelium, smooth muscle cells of myometrium, surface epithelium of endometriumAdachi et al., 2003
    N.D.KidneyRDistal tubules and collecting ductsAdachi et al., 2003
Oatp4a1
    N.D.EyeRCorneal epithelium, ciliary body, iris, retinaIto et al., 2003
Oatp4c1
    BasolateralKidneyRProximal tubule cellsMikkaichi et al., 2004
OATP1A2
    ApicalLiverHCholangiocytesLee et al., 2005a
    ApicalSmall IntestineHEnterocytes at the villus tipGlaeser et al., 2007
    ApicalKidneyHDistal tubulesLee et al., 2005a
    N.D.BrainHCapillary endothelial cellsLee et al., 2005a
OATP1B1
    BasolateralLiverHHepatocytesCui et al., 2003
OATP1B3
    BasolateralLiverHHepatocytes (centrilobular)Cui et al., 2003
OATP1C1
    N.D.TestesHLeydig cellsPizzagalli et al., 2002
OATP2B1
    BasolateralLiverHHepatocytesGrube et al., 2006a
    BasolateralPlacentaHSyncytiotrophoblastsSt-Pierre et al., 2002; Grube et al., 2007
    ApicalSmall IntestineHEnterocytesKobayashi et al., 2003
    N.D.HeartHVascular endotheliumGrube et al., 2006a
OATP4A1
    ApicalPlacentaHSyncytiotrophoblastsSato et al., 2003

  • N.D., not determined.