TABLE 4

Subcellular localization of uptake Oct, Octn, Oat, and Urat transporters in various species

For each transporter, the apical or basolateral localization in a particular tissue and/or species is provided. Species included rat (R), mouse (M), human (H), and bovine (B). Detailed information regarding particular cellular populations or regions of the tissue are provided for some transporter isoforms.

Cellular LocalizationTissueSpeciesCell TypesReferences
Oct1
    BasolateralLiverRHepatocytes (centrilobular)Meyer-Wentrup et al., 1998
    BasolateralKidneyRProximal tubule cells (S1/S2)Karbach et al., 2000
    BasolateralJejunumHEnterocytesMuller et al., 2005
    BasolateralTestesRSertoli cellsMaeda et al., 2007a
    ApicalLungR, HCiliated epithelial cellsLips et al., 2005
Oct2
    BasolateralKidneyR, HProximal tubule cells (S2/S3)Karbach et al., 2000; Motohashi et al., 2002
    ApicalLungR, HCiliated epithelial cellsLips et al., 2005
    ApicalChoroid plexusREpithelial cellsSweet et al., 2001
    ApicalOlfactory mucosaBEpithelial cellsChemuturi and Donovan, 2007
Oct3
    BasolateralKidneyHProximal tubule cell lineGlube and Langguth, 2008
    BasolateralPlacentaHSyncytiotrophoblastsSata et al., 2005
    ApicalJejunumHEnterocytesMuller et al., 2005
    ApicalTestesRSertoli cellsMaeda et al., 2007a
    ApicalLungR, HCiliated epithelial cellsLips et al., 2005
Octn1
    ApicalKidneyMProximal tubule cellsTamai et al., 2004
    ApicalEyeHCorneal-limbal and conjunctival epitheliumGarrett et al., 2008
    N.D.HeartMEndothelial cells in blood vesselsIwata et al., 2008
Octn2
    ApicalKidneyM, R, HProximal tubule cellsTamai et al., 2001a; Masuda et al., 2006
    ApicalPlacentaHSyncytiotrophoblastsLahjouji et al., 2004; Grube et al., 2005
    ApicalSmall intestineREnterocytesDuran et al., 2005
    ApicalEyeHCorneal-limbal and conjunctival epitheliumGarrett et al., 2008
    ApicalEpididymisMPrincipal cells, spermatozoaYakushiji et al., 2006; Kobayashi et al., 2007
    BasolateralEpididymisREpithelia of distal caput and corpusRodriguez et al., 2002
    BasolateralTestesRSertoli cellsKobayashi et al., 2005a
    BasolateralBrainRCapillary endothelial cellsMiecz et al., 2008
    N.D.BrainM, ROlfactory bulb and nerve, cortex, cerebellum, spinal cord, hippocampus, hypothalamus, choroid plexus, astrocytesInazu et al., 2006; Lamhonwah et al., 2008
    N.D.PancreasMα CellsKai et al., 2005
    N.D.HeartM, HCardiac muscle cells, endothelial cellsGrube et al., 2006b; Iwata et al., 2008
Octn3
    BasolateralSmall intestineREnterocytesDuran et al., 2005
    N.D.EpididymisMSpermatozoaKobayashi et al., 2007
    N.D.BrainMOlfactory bulb and nerve, cortex, cerebellum, grey matter, hippocampus, hypothalamus, choroid plexusLamhonwah et al., 2008
Oat1
    BasolateralKidneyM, R, HProximal tubule cellsHosoyamada et al., 1999; Tojo et al., 1999; Eraly et al., 2006
    BasolateralChoroid plexusMEpendymal cellsBahn et al., 2005
    N.D.MuscleHSkeletal muscle cellsTakeda et al., 2004
    N.D.Adrenal glandROuter zona fasciculateBeery et al., 2003
Oat2
    BasolateralLiverRHepatocytesSimonson et al., 1994
    BasolateralKidneyHProximal tubule cellsEnomoto et al., 2002b
    ApicalKidneyM, RProximal tubule cellsKojima et al., 2002; Ljubojevic et al., 2007
Oat3
    BasolateralKidneyM, R, HProximal tubule cellsCha et al., 2001; Kojima et al., 2002; Bahn et al., 2005
    BasolateralEyeRRetinal vascular endothelial cellsHosoya et al., 2008
    BasolateralBrainRCapillary endothelial cellsKikuchi et al., 2003; Roberts et al., 2008
    ApicalChoroid plexusMEpithelial cellsSweet et al., 2002; Sykes et al., 2004
    N.D.MuscleHSkeletal muscle cellsTakeda et al., 2004
Oat4
    ApicalKidneyHProximal tubule cellsBabu et al., 2002a; Ekaratanawong et al., 2004
    BasolateralPlacentaHSyncytiotrophoblastsUgele et al., 2008
Oat5
    ApicalKidneyRProximal tubule cellsAnzai et al., 2005
Oat6
    N.D.Olfactory mucosaMOlfactory cellsMonte et al., 2004
Oat7
    BasolateralLiverHHepatocytesShin et al., 2007
Urat1
    ApicalKidneyM, HProximal tubule cellsEnomoto et al., 2002a; Hosoyamada et al., 2004
  • N.D., not determined.