TABLE 5

Subcellular localization of uptake Pept, Cnt, Ent, and efflux Mate transporters in various species

For each transporter, the apical or basolateral localization in a particular tissue and/or species is provided. Species included rat (R), mouse (M), human (H), and bovine (B). Detailed information regarding particular cellular populations or regions of the tissue are provided for some transporter isoforms.

Cellular LocalizationTissueSpeciesCell TypesReferences
Pept1
    ApicalSmall intestineREnterocytesOgihara et al., 1999
    ApicalKidneyRProximal tubule cellsShen et al., 1999
    ApicalLiverMCholangiocytesKnutter et al., 2002
    IntracellularPancreasRAcinar cells (lysosomes)Bockman et al., 1997
Pept2
    ApicalKidneyM, RProximal tubule cellsShen et al., 1999; Rubio-Aliaga et al., 2000
    ApicalBrainRChoroid plexusShu et al., 2002; Shen et al., 2004
    ApicalMammary glandRGlandular and ductal epithelial cellsGroneberg et al., 2002
    ApicalLungM, R, HTracheal and bronchial epithelial cells, Alveolar Type 2 pneumocytesGroneberg et al., 2001; Bahadduri et al., 2005
    N.D.Nasal mucosaREpithelial cellsQuarcoo et al., 2008
    N.D.IntestineMGlial cells and macrophagesRuhl et al., 2005
Cnt1
    ApicalSmall intestineR, HEnterocytesHamilton et al., 2001; Govindarajan et al., 2007
    ApicalKidneyR, HProximal tubule cellsHamilton et al., 2001; Govindarajan et al., 2007
    ApicalLiverRHepatocytesHamilton et al., 2001; Duflot et al., 2002
Cnt2
    ApicalKidneyHProximal tubule cellsGovindarajan et al., 2007
    ApicalSmall intestineHEnterocytesGovindarajan et al., 2007
    BasolateralLiverR, HHepatocytesDuflot et al., 2002; Govindarajan et al., 2008
Cnt3
    Apical/IntracellularKidneyHProximal tubule cells, loop of HenleDamaraju et al., 2007; Errasti-Murugarren et al., 2007
Ent1
    ApicalPlacentaHSyncytiotrophoblasts, endothelial cellsGovindarajan et al., 2007
    Apical/BasolateralKidneyHProximal/distal tubule cells, Loop of Henle, collecting duct, corticomedullary junctionMangravite et al., 2003; Damaraju et al., 2007; Govindarajan et al., 2007
    BasolateralLiverHHepatocytesGovindarajan et al., 2008
    LateralSmall intestineHEnterocytes, crypt cellsGovindarajan et al., 2007
Ent2
    BasolateralLiverHHepatocytesGovindarajan et al., 2008
    BasolateralKidneyHEpithelial cellsMangravite et al., 2003
    LateralSmall intestineHEnterocytes, crypt cellsGovindarajan et al., 2007
    N.D.HeartRSinoatrial node, atrial and ventricular cellsMusa et al., 2002
MATE1
    ApicalLiverM, HHepatocytes, cholangiocytesOtsuka et al., 2005
    ApicalKidneyR, HProximal and distal tubule cellsOtsuka et al., 2005; Masuda et al., 2006; Nishihara et al., 2007
    ApicalKidneyMCortical collecting ducts, proximal tubules, Thin limb of loop of HenleOtsuka et al., 2005
Mate2
    N.D.TestesMLeydig cellsHiasa et al., 2007
MATE2-K
     ApicalKidneyHProximal tubule cellsMasuda et al., 2006; Tanihara et al., 2007
  • N.D., not determined.