TABLE 6

Subcellular localization of efflux Mdr transporters in various species

For each transporter, the apical or basolateral localization in a particular tissue and/or species is provided. Species included rat (R), mouse (M), human (H), and bovine (B). Detailed information regarding particular cellular populations or regions of the tissue are provided for some transporter isoforms.

Cellular LocalizationTissueSpeciesCell TypesReferences
Mdr1a/1b/MDR1
    ApicalLiverH, RHepatocytes, cholangiocytesGigliozzi et al., 2000; Scheffer et al., 2002c
    ApicalBrainM, REndothelial cells, choroid plexusSchinkel et al., 1994; Rao et al., 1999; Miller et al., 2000
    ApicalPlacentaM, HSyncytiotrophoblastsLankas et al., 1998; St-Pierre et al., 2000
    ApicalFetal membranesMVisceral yolk sacLankas et al., 1998
    ApicalColonMEpithelial cellsPanwala et al., 1998
    ApicalPancreasHSmall epithelial ductsScheffer et al., 2002b
    ApicalSmall intestineREnterocytes (jejunum/ileum)Ujhazy et al., 2001; Rost et al., 2002
    ApicalLungHBronchial and bronchiolar epitheliumScheffer et al., 2002c
    ApicalKidneyR, HProximal tubule cellsJette et al., 1996; Ernest et al., 1997
    N.D.TestesHMyoid, Leydig, capillary endothelial cellsBart et al., 2004
    N.D.Inner earMCapillary endothelial cellsZhang et al., 2000
    N.D.Adrenal glandHCortexScheffer et al., 2002b
Mdr2/MDR3
    ApicalLiverM, HHepatocytesBuschman et al., 1992; de Vree et al., 1998

  • N.D., not determined.