Effect of withdrawal from long-term benzodiazepine treatment on GABAA receptor subunit polypeptide expression in cultured cells in vitro
| Cells, Compound, Concentration, Duration, Withdrawal Time | Subunit Polypeptide | Reference | ||
|---|---|---|---|---|
| α1 | α4 | γ2 | ||
| % change | ||||
| Rat hippocampal neurons | ||||
| Etizolam, 10 μM, 5 d/6 h | N.S. | N.S. | Sanna et al., 2005 | |
| Lorazepam, 10 μM, 5 d/6 h | −26 | +81 | Sanna et al., 2005 | |
| Rat cerebellar granule cells | ||||
| Diazepam, 10 μM, 5 d/6 h | −75 | +45 | −63 | Follesa et al., 2001a |
d, day(s); N.S., not significantly different from the control value.