TABLE 12

Effect of long-term pentobarbital treatment in vivo on GABAA receptor subunit mRNA expression

Species, Dose, Duration, Regimen, Brain RegionSubunit mRNAReference
α1α6β1β3γ2δ
% change
Rat, 30 mg/kg, 14 dMorrow et al., 1990
Intraperitoneal injection
    Cerebral cortexN.S.
Rat, increasing doseMorrow et al., 1991
30 mg->120 mg/kg, 14 d
Intraperitoneal injection
    Cerebral cortexN.S.
Rat, 7.2 mg/d,a 6 dTseng et al., 1993a
Infusion, osmotic minipump
    NeocortexN.S.
    Piriform cortexN.S.
    HippocampusN.S.
    Caudate putamenN.S.
    Medial habenular nucleusN.S.
    ThalamusN.S.
    Superior colliculus−12
    Inferior colliculus−8
    Central grayN.S.
    CerebellumN.S.
Rat, 7.2 mg/d,a 6 dTseng et al., 1994
Infusion, osmotic minipump
    NeocortexN.S.N.S.
    Piriform cortexN.S.N.S.
    Hippocampus
        CA1−19N.S.
        CA3−10N.S.
        Dentate gyrus−10N.S.
    Caudate putamenN.S.N.S.
    Medial habenular nucleusN.S.N.S.
    ThalamusN.S.—
    Superior colliculus−25—
    Inferior colliculus−16—
    Central grayN.S.—
    Cerebellum
        Molecular cellsN.S.—
        Granule cellsN.S.N.S.
        Purkinje cellsN.S.—
Rat, 7.2 mg/d,a 6 dIto et al., 1996a
Infusion, osmotic minipump
    Cerebellum
        Granule cells+47
Mouse, 3×75 mg/d, 7 dLin and Wang, 1996
Infusion, osmotic minipump
    Frontal cortexN.S.
    Cerebellum+44
Rat, increasing doseYin and Lee, 1998
30 mg->120 mg/kg, 9 d
Intraperitoneal injection
    Hippocampus
        CA1+636
        CA2+623
        CA3N.S.
        CA4N.S.
        Dentate gyrusN.S.

  • d, day(s); N.S., not significantly different from the control value; —, not detected.

  • ↵a Continuous infusion.