TABLE 14

Effect of long-term ethanol treatment in vivo on GABA_A receptor α subunit mRNA expression

Species, Dose, Duration, Regimen, Brain Region	Subunit mRNA						Reference
Species, Dose, Duration, Regimen, Brain Region	α1	α2	α3	α4	α5	α6	Reference
	% change
Rat, 14 d							Morrow et al., 1990
Inhalation, BEC > 150 mg/100 ml
Cerebral cortex	−45
Rat, 14 d							Montpied et al., 1991
Inhalation, BEC > 150 mg/100 ml
Cerebral cortex	−49	−29	N.S.
Rat, 14 d, BEC > 150 mg/100 ml							Morrow et al., 1991
Inhalation
Cerebral cortex	−45	−29	N.S.
Rat, 8–10 g/kg/d, 14 d							Morrow et al., 1992
Forced ethanol drinking
Cerebellum	−20					+50
Rat, 5 g/kg/d, 6 d							Mhatre and Ticku, 1992
Intragastric intubation
Cerebral cortex	−61	−61, −45	N.S.		−51
Cerebellum	−28					+76
Rat, 10–12 g/kg/d, 14 d							Devaud et al., 1995
Forced ethanol drinking
Cerebral cortex	−43			+89	N.S.
Mouse, 5 g/kg/d, 14 d							Wu et al., 1995
Intragastric intubation
Cerebellum
Purkinje cell layer	−40
Granule cell layer	−23					+36
Deep cerebellar cells	−40
Rat, 10 g/kg/d, 84 d							Charlton et al., 1997
EtOH cont. liquid diet
Hippocampus	−47				+64
Rat, 5 g/kg/d, 18 months							Sarviharju et al., 2006
Forced ethanol drinking
Frontoparietal cortex	N.S.	N.S.	N.S.	N.S.	N.S.	N.S.
Olfactory bulb	N.S.	N.S.	N.S.	N.S.	N.S.	N.S.
Olfactory tubercle	N.S.	N.S.	N.S.	−30	N.S.	N.S.

d, day(s); BEC, blood ethanol concentration; N.S., not significantly different from the control value.