Effect of long-term ethanol treatment on GABAA receptor subunit mRNA expression in cultured cells in vitro
| Cells, [EtOH], Treatment Time | Subunit mRNA | Reference | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| α1 | α2 | α3 | α4 | α5 | α6 | β2 | β3 | γ2 | δ | ||
| % change | |||||||||||
| Rat hippocampal neurons | |||||||||||
| 100 mM, 5 d | −24 | N.S. | −23 | N.S. | N.S. | −22, −34a | Sanna et al., 2003 | ||||
| 100 mM, 5 d | +120 | Follesa et al., 2005 | |||||||||
| Rat cerebellar granule cells | |||||||||||
| 100 mM, 5 d | N.S. | N.S. | N.S. | −23, −32a | Follesa et al., 2003 | ||||||
| 100 mM, 5 d | N.S. | Follesa et al., 2004 | |||||||||
| 100 mM, 5 d | N.S. | Follesa et al., 2005 | |||||||||
| Mouse cortical neurons | |||||||||||
| 75 mM, 5 d | −24 | −24 | N.S. | N.S. | N.S. | −32 | Sheela Rani and Ticku, 2006 | ||||
| 75 mM, 5 d, CIE | −55 | −52 | 48 | N.S. | N.S. | −29 | Sheela Rani and Ticku, 2006 | ||||
d, day(s); N.S., not significantly different from the control value.
↵a Two values represent S and L splice variants, respectively.