Effect of withdrawal from long-term ethanol treatment on GABAA receptor subunit mRNA expression in cultured cells in vitro
| Cells, [EtOH], Duration, Withdrawal Time | Subunit mRNA | Reference | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| α1 | α2 | α3 | α4 | α5 | α6 | β2 | β3 | γ2 | δ | ||
| % change | |||||||||||
| Rat hippocampal neurons | |||||||||||
| 100 mM, 5 d, 3 h | −15 | +30 | +40 | +30 | N.S. | −21, −40a | Sanna et al., 2003 | ||||
| 100 mM, 5 d, 9 h | N.S. | Follesa et al., 2005 | |||||||||
| Rat cerebellar granule cells | |||||||||||
| 100 mM, 5 d, 3–12 h | −29 | +46 | −27 | −76, −64a | Follesa et al., 2003 | ||||||
| 100 mM, 5 d, 3 h | +159 | Follesa et al., 2004 | |||||||||
| 100 mM, 5 d, 6 h | −27 | Follesa et al., 2005 | |||||||||
| 100 mM, 5 d, 6 h | −22 | +160 | +43 | −28 | −33, −22a | −23 | Biggio et al., 2007 | ||||
| Mouse cortical neurons | |||||||||||
| 75 mM, 5 d, 5d | N.S. | N.S. | N.S. | N.S. | N.S. | N.S. | Sheela Rani and Ticku, 2006 | ||||
| 75 mM, 5 d, 5d, CIE | N.S. | N.S. | N.S. | N.S. | N.S. | N.S. | Sheela Rani and Ticku, 2006 | ||||
d, day(s); N.S., not significantly different from the control value.
↵a Two values represent S and L splice variants, respectively.