TABLE 3

Carboxyl-terminal protein binding partners for AMPA and kainate receptor subunits

Entries indicate data supporting direct interactions between the indicated protein and glutamate receptor subunit.

ProteinClassGluA1GluA2GluA3GluA4GluK1GluK2GluK5
CASKPDZY2H,coIP,EP1
GRIPPDZY2H,coIP,IHC2,3,4,5Y2H,coIP,IHC2,3,4,6Y2H,coIP,IHC7Y2H,coIP,EP8
GRIP2PDZY2H,coIP,IHC4,5,7Y2H,coIP,IHC4,7Y2H,coIP,IHC7Y2H,coIP,EP8
mLIN-10PDZcoIP9coIP9
PICK1PDZY2H,coIP,IHC2,6Y2H,coIP,IHC2,6Y2H,coIP,IHC2,6Y2H,coIP,EP8Y2H,coIP,EP8
PSD95PDZY2H,coIP,EP8Y2H,coIP,IHC,EP8,10coIP,IHC,EP10
SAP97PDZcoIP,IHC11,12Y2H,coIP,EP10
SAP102PDZY2H,coIP,EP10
Shank3PDZY2H,coIP,IHC13
SynteninPDZY2H14Y2H14Y2H14Y2H14Y2H,coIP,EP8Y2H,coIP,EP8
RILPDZ / LIMY2H,coIP,IHC,EP15
4.1CytoskeletalY2H,coIP,IHC16,17coIP,IHC18
α-Actinin-1CytoskeletalY2H,coIP,IHC19
ActinfilinCytoskeletalY2H,coIP,IHC20Y2H,coIP,IHC20
ContactinCytoskeletalcoIP21
Dynamin-1CytoskeletalcoIP21
DynamitinCytoskeletalcoIP21
ProfilinScaffoldcoIP21
SpectrinScaffoldcoIP21
AP2AdaptorcoIP,IHC,EP22,23
NSFATPaseY2H,coIP,IHC,EP24,25,26coIP21
IQGAP1GTPaseY2H,coIP,IHC19
CalmodulinCa2+ sensorcoIP21
VILIP1Ca2+ sensorcoIP21
VILIP3Ca2+ sensorcoIP21
14-3-3Other27coIP21coIP28
COPIOther27coIP28
G-α(q/11)Other27coIP,EP29
SUMOOther27Y2H,coIP,IHC,EP30

  • coIP, coimmunoprecipitation or pull-down assay; EP, electrophysiology; IHC, immunohistochemistry; Y2H, yeast two-hybrid.

  • ↵1 Coussen et al. (2002).

  • ↵2 Dev et al. (1999).

  • ↵3 Dong et al. (1997).

  • ↵4 Wyszynski et al. (1999).

  • ↵5 Dong et al. (1999).

  • ↵6 Xia et al. (1999).

  • ↵7 Srivastava et al. (1998).

  • ↵8 Hirbec et al. (2003).

  • ↵9 Stricker and Huganir (2003).

  • ↵10 Garcia et al. (1998).

  • ↵11 Leonard et al. (1998).

  • ↵12 Sans et al. (2001).

  • ↵13 Uchino et al. (2006).

  • ↵14 Hirbec et al. (2002).

  • ↵15 Schulz et al. (2004).

  • ↵16 Hayashi et al. (2005).

  • ↵17 Shen et al. (2000).

  • ↵18 Coleman et al. (2003).

  • ↵19 Nuriya et al. (2005).

  • ↵20 Salinas et al. (2006).

  • ↵21 Coussen et al. (2005).

  • ↵22 Kastning et al. (2007).

  • ↵23 Lee et al. (2002).

  • 24 Nishimune et al. (1998).

  • 25 Osten et al. (1998).

  • 26 Song et al. (1998).

  • ↵27 Synaptic transmembrane proteins, signaling proteins, ubiquitin-like proteins, or transport regulatory proteins.

  • ↵28 Vivithanaporn et al. (2006).

  • ↵29 Ruiz et al (2005).

  • ↵30 Martin et al. (2007).