Actions and affinities of endogenous apelin receptor agonists
| Ligand | Action | Affinity (pIC50) | References |
|---|---|---|---|
| Apelin-36 | Full agonist | 8.6–8.3 | Hosoya et al., 2000; Kawamata et al., 2001; Fan et al., 2003; Medhurst et al., 2003 |
| Apelin-17 | Full agonist | 9.0–7.9 | Medhurst et al., 2003; El Messari et al., 2004 |
| (Pyr1)apelin-13 | Full agonist | 8.9–8.0 | Hosoya et al., 2000; Medhurst et al., 2003; El Messari et al., 2004 |
| Apelin-13 | Full agonist | 9.2–8.8 | Fan et al., 2003; Medhurst et al., 2003 |