TABLE 3

Deorphanized G protein-coupled receptors other than GPR55 that could possibly be activated by cannabinoid receptor ligands

In all cases, it was not reported whether the receptor was targeted by cannabinoid receptor ligands. See Section III.B for references and further details.

ReceptorRecognized Agonist(s)EC50 Range
FFA1 (GPR40Fatty acids (C6-C22)Micromolar
FFA2 (GPR43)Fatty acids (C1-C6)Micromolar to millimolar
FFA3 (GPR41)Fatty acids (C1-C6)Micromolar to millimolar
GPR84Fatty acids (C9-C14)Micromolar
GPR120Fatty acids (C14-C22)Micromolar
GPR3Sphingosine-1-phosphate?
GPR6Sphingosine-1-phosphate?
GPR12Sphingosylphosphorylcholine?
GPR18LPANanomolar to micromolar
Farnesyl pyrophosphateNanomolar to micromolar
NAGlyNanomolar to micromolar
GPR23LPA?
GPR119OEA/OLDALow micromolar
  • OEA, oleoyl ethanolamide; OLDA, N-oleoyl dopamine.