TABLE 2

Characteristics of human Class FZD receptors

Information compiled from www.uniprot.org.

ReceptorGene Name: Human (Rat/Mouse)NCBI Accession No.Chromosomal LocationUniProtKB/SwissProt Accession No.Protein LengthMolecular MassNumber ofC TerminusIUPHAR Database URL
TranscriptsExons
aakDa
FZD1FZD1 (Fzd1)NP_0034967q21Q9UP3864771,15811ETTV (+)http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?familyId=25&objectId=229
FZD2FZD2 (Fzd2)NP_00145717q21.1Q1433256563,55411ETTV (+)http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?familyId=25&objectId=230
FZD3FZD3 (Fzd3)NP_0591088p21Q9NPG166676,26318GTSA (+)http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=231&familyId=25
FZD4FZD4 (Fzd4)NP_03632511q14.2Q9ULV153759,88112ETVV (+)http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=232&familyId=25
FZD5FZD5 (Fzd5)NP_0034592q33-q34Q1346758564,50712LSHV (+)http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=233&familyId=25
FZD6FZD6 (Fzd6)NP_0034978q22.3-q23.1O6035370679,29217HSDT (−)http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=234&familyId=25
FZD7FZD7 (Fzd7)NP_0034982q33O7508457463,62011ETAV (+)http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=235&familyId=25
FZD8FZD8 (Fzd8)NP_11407210p11.22Q9H46169473,30011LSQV (+)http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=236&familyId=25
FZD9FZD9 (Fzd9)NP_0034997q11.23O0014459164,46611PTHL (−)http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=237&familyId=25
FZD10FZD10 (Fzd10)NP_00912812q24.33Q9ULW258165,33611PTCV (+)http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=238&familyId=25
SMOSMO (Smo)NP_0056227q32.3Q9983578786,397425DSDF (+)http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=239&familyId=25

  • + or − in the C Terminus column indicates experimental evidence for or against, respectively, the functionality of the class Frizzled receptor C terminus as PDZ ligand domain.