Phenotypes of mice with altered class Frizzled receptor expression
| Receptor | Genotype | Phenotype | References |
|---|---|---|---|
| FZD1 | Unknown | Viable | van Amerongen and Berns, 2006 |
| FZD2 | Unknown | Viable | van Amerongen and Berns, 2006 |
| FZD3 | FZD3(−/−) | Postnatally lethal, Severe defects in major axon tracts within the forebrain | Wang et al, 2002 |
| Anterior-posterior guidance of commissural axons | Lyuksyutova et al, 2003 | ||
| FZD3(−/−), FZD6(−/−) | Severe midbrain morphogenesis defect | Stuebner et al, 2010 | |
| FZD4 | FZD4(−/−) | Cerebellar, auditory, and esophageal dysfunction | Wang et al, 2001 |
| FZD4(−/−) | Infertility and impaired corpora lutea formation and function | Hsieh et al, 2005 | |
| Fz4CKOAP/−;Tie2-Cre (endothelium) | Defects in vascular growth, endothelial defects | Ye et al, 2009b | |
| FZD5 | FZD5(−/−) | Embryonically lethal, essential for yolk sac and placental angiogenesis | Ishikawa et al, 2001 |
| Fz5LoxP/LoxP-K19Cre (intestinal epithelium) | Paneth cell phenotype | van Es et al, 2005 | |
| Fz5CKO-AP/lacZ;Sox2-Cre and Fz5CKO-AP/lacZ;R26-CreER | Neuronal survival, ocular development and late onset retinal degeneration | Liu and Nathans, 2008; Liu et al, 2008a | |
| FZD6 | Fz6(−/−) nlacZ | Hair patterning, tissue polarity | Guo et al, 2004 |
| FZD7 | Unknown | Viable | van Amerongen and Berns, 2006 |
| FZD8 | Unknown | Viable | van Amerongen and Berns, 2006 |
| FZD9 | FZD9(−/−) | Abnormal B cell development, moderately reduced lifespan, splenomegaly, and accelerated thymic atrophy | Ranheim et al, 2005 |
| FZD9(−/−) IRES lacZ | Developmental neuroanatomical defects in hippocampus and visuospatial learning deficits (comparable to Williams syndrome) | Zhao et al, 2005 | |
| FZD10 | van Amerongen and Berns, 2006 | ||
| SMO | SMO(−/−) | Embryonically lethal, defects in L/R patterning | Zhang et al, 2001 |