R1 | R2 | Ki | EC50 | RIA | R1 | Ki | EC50 | RIA |
---|---|---|---|---|---|---|---|---|
μM | % | μM | % | |||||
Nicotinic acid | 0.033 | 0.74 | 100 | C6H5-CH2- | 1.3 | 87 | 50 | |
H | H | 0.59 | 22 | 85 | C6H5-(CH2)2- | 1.6 | N.D. | N.D. |
i-C3H7 | H | 0.68 | 22 | 68 | C6H5-(CH2)3- | 6.3 | N.D. | n.d. |
C3H7 | H | 0.14 | 5.1 | 70 | 3Cl-C6H4-CH2- | 0.50 | 47 | 39 |
C4H9 | H | 0.072 | 2.3 | 81 | 4Cl-C6H4-CH2- | 3.6 | N.D. | N.D. |
-C3H6- | 0.16 | 7.0 | 56 | 4-CH3-C6H4-CH2- | 20 | N.D. | N.D. | |
-C4H8- | 3.5 | 65 | 47 | 4-OCH3-C6H4-CH2- | 66 | N.D. | N.D. |
N.D., not determined.