The physiochemical characteristics of benzodiazepine receptor agonists commonly used in the practice of anesthesia
Water solubility values are in unbuffered water, maximal solubility at acidic pH in parenthesis. Data from http://scifinder.cas.org.
| Molecular Weight | pKa | Water Solubility | Lipid Solubility | |
|---|---|---|---|---|
| Da | g/l | Log P | ||
| Diazepam | 284.7 | 3.4 | 0.051 | 2.801 |
| Lorazepam | 321.2 | 1.3 | 0.12 | 2.382 |
| Temazepam | 300.7 | 1.6, 11.7 | 0.28 | 2.188 |
| Midazolam | 325.8 (hydrochloride 362.2) | 6.0 | 0.004 (2.0, pH 1) | 3.798 |
| Remimazolam | 439.3 (besylate 597.5) | 5.3 | 0.008 (7.5, pH 1) | 3.724 |
| Flumazenil | 303.3 | 0.86 | 0.042 | 2.151 |
pKa, dissociation constant.