Theoretical AUC values for an oral drug in various mouse strains assuming additive, synergistic, or competitive (= antagonistic) functioning of CYP3A and P-gp
| Cyp3a/P-gp(−/−) (−) | P-gp(−/−) (+CYP3A) | Cyp3a(−/−) (+P-gp) | WT (+CYP3A+P-gp) | |
|---|---|---|---|---|
| Additive | 100 | 5 | 20 | 1 |
| Synergistic | 100 | 25 | 20 | 1 |
| Competitive | 100 | 4 | 5 | 1 |