Compound | Structure | Potencies | Comments | References |
---|---|---|---|---|
I: AMN082 | EC50 = 260 nM | Allosteric agonist, the first selective agonist for the mGlu7 receptor; active in vivo in various animal models. | Mitsukawa et al., 2005 | |
II: MDIP | IC50 = 20 nM | Negative allosteric mGlu7 receptor modulator | Suzuki et al., 2007 | |
III: MMPIP | IC50 = 26 nM | Negative allosteric mGlu7 receptor modulator with inverse agonist activity Inhibits effects of AMN082 in vitro |
MDIP, 5-methyl-3,6-diphenylisoxazolo[4,5-c]pyridin-4(5H)-one.