Compound | Structure | Potency/Affinity (EC50) | Comments | References |
---|---|---|---|---|
I: Ro 01-6128 | 200 nM | Knoflach et al., 2001 | ||
II: Ro 67-4853 | 69 nM | First positive mGlu receptor modulators ever described. Only II is active at both rat and human receptors; I and III do not modulate human mGlu1 | Knoflach et al., 2001 | |
III: Ro 67-7476 | 174 nM | Knoflach et al., 2001 | ||
IV: VU-71 | 2.4 μM | Hemstapat et al., 2006 | ||
V: Ro 07-11401 | 56 nM | Active in EAE-model for multiple sclerosis in mice | Vieira et al., 2009 |
EAE, experimental autoimmune encephalomyelitis.