Dose-dependent efficacy and toxicity of 6-week simvastatin
Data from Davidson et al. (1997). Cholesterol change calculated from baseline LDL cholesterol of ∼199 mg/dl (n = 147). Values in parentheses indicate S.D. (second column) and percentages (fourth and fifth columns).
| Dose and No. of Patients | LDL Cholesterol Change | Patients with | ||
|---|---|---|---|---|
| Median | Range | Myopathy | ALT Elevation | |
| % | n (%) | |||
| 40 mg/day (n = 141) | −41 (−48 to −32) | −64–11 | 0 | 0 |
| 80 mg/day (n = 144) | −47 (−53 to −37) | −65–30 | 0 | 1 (0.7) |
| 160 mg/day (n = 140) | −53 (−59 to −45) | −71–19 | 1 (0.7) | 3 (2.1) |
ALT, alanine aminotransferase.