NHERF effects on PTHR signaling
| Cell type | NHERF Isoform | Effect | Reference |
|---|---|---|---|
| PS120 | NHERF1/2 | Increased PLC activity | Mahon et al., 2002 |
| Increased Gαi and decreased adenylyl cyclase activity | |||
| ROS | NHERF1 | Increased PLC activity and cAMP and Ca2+ accumulation | Wheeler et al., 2008 |
| Renal tubule cells | NHERF1 | Increased PLC activity | Cunningham et al., 2005 |
| No changes in cAMP accumulation | Capuano et al., 2007 | ||
| CHO-N10-R3 | NHERF1 | No changes in cAMP accumulation | Wang et al., 2007 |
| Decreased ERK1/2 stimulation | Wang et al., 2008 | ||
| OK | NHERF1/2 | Increased PLC activity | Mahon and Segre, 2004 |
| Increased Ca2+ accumulation | |||
| HEK293 | NHERF1/2 | NHERF1: increased Gαq activity and Ca2+ accumulation | Wang et al., 2010 |
| NHERF2: increased Gαq and Gαi and decreases Gαs activity | |||
| Increased Ca2+ and decreases cAMP accumulation |