Group B SRCR proteins
Proteins described in mammals, unless indicated otherwise.
| Name | No. SRCR | Other Domains | Expression | Function | Form | References |
|---|---|---|---|---|---|---|
| CD5 | 3 | Thymocytes, T and B1a lymphocytes; mammals and Gallus gallus (chicken) | Modulation of TCR and BCR signaling | M, S | Jones et al., 1986 | |
| CD6 | 3 | Thymocytes, T and B1a lymphocytes, neurons; mammals and G. gallus (chicken) | Modulation of TCR signaling; binding to ALCAM/CD166 | M, S | Aruffo et al., 1997 | |
| T19/WC1 | 11 | Tγδ lymphocytes | Reversible G0/G1 cell cycle arrest | M | Wijngaard et al., 1992 | |
| M130/CD163 | 9 | Macrophages | Haptoglobin-hemoglobin receptor; role in inflammation; binding to bacteria | M, S | Law et al., 1993 | |
| M160 | 12 | Macrophages | Role in inflammation | M | Gronlund et al., 2000 | |
| DMBT1/gp340/SAG/Hensin/Ebnerin/CRP-ductin/BGM/H3 | 4–14 | CUB, ZP | Intestinal epithelium, kidney, lung, liver, stomach, pancreas, prostate, von Ebner's gland, brain, heart | Epithelial differentiation and polarization; binding to galectin-3; binding to SP-D and SP-A; binding to bilirubin and cholesterol; binding to bacteria, fungi, and gp120 from HIV-1; suppression of infection and inflammation | M, S | Li and Snyder, 1995; Nunes et al., 1995; Cheng et al., 1996; Takito et al., 1996; Mollenhauer et al., 1997 |
| Pema-SREG | 2 | Petromyzon marinus (sea lamprey) intestine | Unknown | M | Mayer and Tichy, 1995 | |
| Spα/AIM | 3 | Tissue macrophages | Apoptosis inhibitory factor; binding to PAMPs from bacteria and fungi; adipocyte lipolysis | S | Gebe et al., 1997; Miyazaki et al., 1999 | |
| 18-B | 4 | Unknown; described in G. gallus | APR | S | Iwasaki et al., 2001 | |
| SCART1/2 | 8 | Tγδ lymphocytes, lymph node, trachea, lung, and low expression in thymus, spleen, skin, and tissues throughout the gastrointestinal tract. | Role in inflammation and T cell development | M, S | Kisielow et al., 2008; Holm et al., 2009 | |
| S4D-SRCRB | 4 | Heart, liver, brain, PBL, spleen, intestine, kidney, and placenta | Unknown | S | Padilla et al., 2000 | |
| S5D-SRCRB/SSc5D | 5 | Syndecan domain | Genitourinary and digestive tracts | Binding to PAMPs from bacteria and fungi, and to ECM and Galectin-3 | S | Gonçalves et al., 2009; Miró-Julià et al., 2011 |
| MAP_GEOCY | 1 | Fibronectin, SCR | Extracellular matrix of G. cydonium (marine sponge) | Multiadhesive protein | S | Pahler et al., 1998 |
| PSLAP | 2 | LCCL, PLAT | Plasmodium falciparum (parasite) gametocytes | Mosquito and/or vertebrate immune response evasion | S | Delrieu et al., 2002 |
APR, acute phase reactant; BCR, B-cell receptor; EGF, epidermal growth factor; LCCL, Limulus factor C, Coch-5b2, and Lgl1 domain; M, membrane; PBL, peripheral blood leukocytes; PLAT, polycistin-1, lipoxygenase, and α-toxin domain; S, secreted; SCR, short consensus repeat.