Variable effects of nicotine on parkinsonism in animal models with nigrostriatal damage
| Animal Model & Change in Parkinsonism | Drug | Study Duration | Reference |
|---|---|---|---|
| 6-OHDA-lesioned rat | |||
| None | Nicotine | Weeks | Bordia et al., 2008 |
| Improvement | Nicotine | Acute dose | Meshul et al., 2002 |
| 6-OHDA-lesioned mouse | |||
| None | Nicotine | Weeks | Huang et al., 2011 |
| MPTP-lesioned monkey | |||
| None | Nicotine | Weeks | Quik et al., 2006b |
| Improvement | Nicotine | Acute dose | Domino et al., 1999 |
| Synergistic with l-DOPA | SIB-1508Y | Acute dose | Schneider et al., 1998 |
6-OHDA, 6-hydroxydopamine.