Selectivity (potency) of phosphodiesterase type 5 (PDE5) inhibitors
| Inhibitor | IC50 for PDE5 | PDE Selectivity | Source |
|---|---|---|---|
| nM | |||
| Sildenafil | 3.5–10 | Low activity against PDE6 | Francis et al. (2009) |
| Vardenafil | 0.14–1 | Low activity against PDE6 | Francis et al. (2009) |
| Tadalafil | 1.8–10 | Low activity against PDE11 | Francis et al. (2009) |
| Udenafil | 8.2 | Low activity against PDE3, PDE6 | Doh et al. (2002) |
| Mirodenafil | 0.33 | “More selective than sildenafil” | Shin et al. (2006) |
| Avanafil | 1 | Low activity against PDE1, PDE6 | Hellstrom (2008) |
| SLx-2101 | 0.24 | N.A. | Sweetnam et al. (2006) |
IC50, half maximal inhibitory concentration; N.A., not available.