Junction Type | Component Proteins |
---|---|
Occluding junction | |
Tight junction | |
Integral membrane proteins | Occludin, claudin-1, -3, -4, -5, -7, -8, -11, JAM-A, JAM-B, CLMP, CAR |
Adaptors | ZO-1, ZO-2, vinculin |
Regulatory or signaling proteins | FAK, c-Src, c-Yes, p38 MAPK, ERK1/2, JNK, PKB (Akt), PAK, PI3K |
Polarity proteins | PAR6, 14–3-3, PATJ, PALS1, Scribble, Crumbs, Cdc42 |
Protease | MMP9 |
Protease inhibitors | TIMP-1, α2-macroglobulin |
Trafficking proteins | Dynamin 2, Rab8B, clathrin, caveolin-1, EEA-1, Rab9, MTMR2, annexin II |
Cytokines | TGF-β2, TGF-β3, TNFα, IL-1α |
Drug transporters | P-glycoprotein (efflux pump), Oatp3 (influx pump) |
Scaffolding proteins | Actin, collagen α3(IV) |
Anchoring junction | |
Cell-cell actin-based | |
Basal ES | |
Integral membrane proteins | N-cadherin, E-cadherin, nectin-2, CAR |
Adaptors | α-catenin, β-catenin, γ-catenin, afadin, vinculin |
Regulatory or signaling proteins | c-Src, c-Yes, CK2, Csk |
Trafficking proteins | Dynamin 2, clathrin, caveolin-1, MTMR2, annexin II |
Drug transporters | Oatp3 |
Scaffolding proteins | Actin |
Actin regulatory proteins | Eps8, Arp2/3 complex, N-WASP, drebrin E |
Cell-cell intermediate filament-based | |
Desmosome | |
Integral membrane proteins | Desmoglein 2, desmocollin 2, desmocollin 3 |
Adaptors | Plakoglobin (γ-catenin), plakophilin-1,- 2,- 4, desmoplakin |
Regulatory or signaling proteins | c-Src, CK2, Csk |
Scaffolding proteins | Vimentin |
Communicating junction | |
Gap junction | |
Integral membrane proteins | Connexin-43, -33, -26, -32, -36, -37, -40, -43, -45, -46, -50, -57 |
Adaptors | Plakophilin 2, β-catenin, drebrin E |
Regulatory or signaling proteins | c-Src |
Scaffolding proteins | Actin |
CK2, casein kinase 2; CLMP, CXADR-like membrane protein; Csk, carboxyl-terminal Src kinase; drebrin E, developmentally regulated brain protein E; EEA-1, early endosome antigen-1; N-WASP, neuronal Wiskott-Aldrich syndrome protein; PAK, p21-activated kinase; PALS1, protein associated with Lin seven-1; PATJ, Pals1-associated tight junction protein; TIMP-1, tissue inhibitor of metalloproteases-1, a metalloprotease inhibitor.