TABLE 11

Conopeptides targeting GPCRs and monoamine transporters

SpeciesDietNameSequenceTargetReference
1234
C. tulipaFρ-TIAFNWRCCLIPACRRNHKKFC*α1-AdrenoceptorSharpe et al., 2001
C. marmoreusMχ-MrIA-NGVCCGYKLCHO-----CNETSharpe et al., 2001
χ-MrIB-VGVCCGYKLCHO-----CNETSharpe et al., 2001
χ-CMrVIA---VCCGYKLCHO-----CN.D.Balaji et al., 2000
χ-CMrX--GICCGVSFCYO-----CN.D.Balaji et al., 2000
C. geographusPConopressin GCFIRNCPKG*
CIIRNCPRG*
Vasopressin RCruz et al., 1987; Nielsen et al., 1994
C. imperialisV
C. striatusPConopressin SCFIRNCOPV1bR, OTR > V1aRCruz et al., 1987; Dutertre et al., 2008
C. textileMConopressin TxCYIQNCLRV*N.D.Ueberheide et al., 2009
C. tulipaPConopressin-TCLIQDCPγG*OT, V1aRDutertre et al., 2008
C. villepiniVConopressin-vilZSEEGGSNAtKKPYIILN.D.Möller and Marí, 2007
C. geographusFContulakin-GZSEEGGSNAtKKPYIILNeurotensin RCraig et al., 1999
  • P, fish; M, molluscs; V, worms; γ, γ-carboxyglutamate;

  • * , C-terminal amidation; N.D., not determined.