TABLE 4

ω-Conotoxins targeting Ca_v calcium channels (loop formula C6C5–9CC–4C3–6C)

Residues identified as being significant for affinity are underlined.

Species	Name	Diet	Sequence Disulfide Bonded (1–4/2–5/3–6)	Ca_v Selectivity	References
Species	Name	Diet	123456	Ca_v Selectivity	References
C. consors	CnVIIA	P	---CKGKGAOCTRLMYD---CC-HGSCSSSKGRC^*	2.2 > 2.1	Favreau et al., 2001
C. catus	CVIA	P	---CKSTGASCRRTSYD---CC-TGSCRS--GRC^*	2.2 > 12.	Lewis et al., 2000
	CVIB	P	---CKGKGASCRKTMYD---CC-RGSCRS--GRC^*	2.2 ∼ 2.1 > 2.3	Lewis et al., 2000
	CVIC	P	---CKGKGQSCSKLMYD---CC-TGSC-SRRGKC^*	2.1 ∼ 2.2	Lewis et al., 2000
	CVID	P	---CKSKGAKCSKLMYD---CC-SGSCSGTVGRC^*	2.2 > 2.1	Lewis et al., 2000
	CVIE-2**	P	---CKGKGASCRRTSYD---CC-TGSCRS--LRC^*	2.2 > 2.1 > 1.2 ∼ 1.3 ∼ 2.3	Berecki et al., 2010
	CVIF	P	---CKGKGASCRRTSYD---CC-TGSCRS--GRC^*	2.2 > 2.1 > 1.2 ∼ 1.3 ∼ 2.3	Berecki et al., 2010
C. fulmen	FVIA	P	---CKGTGKSCSRIAYN---CC-TGSCRS--GKC^*	2.2 > 2.1 > 3.2	Lee et al., 2010
C. geographus	GVIA	P	---CKSOGSSCSOTSYN---CC--RSCNOYTKRCY^*	2.2 > 2.1	Olivera et al., 1984; Sato et al., 1993; Kim et al., 1994; Kim et al., 1995
	GVIIA	P	---CKSOGTOCSRGMRD---CC--TSCLLYSNKCRRY	Mouse ∼ fish > frog	Olivera et al., 1985; Abe and Saisu, 1987
	GVIIB	P	---CKSOGTOCSRGMRD---CC--TSCLSYSNKCRRY	Mouse ∼ fish > frog	Olivera et al., 1985; Abe and Saisu, 1987
C. magus	MVIIA	P	---CKGKGAKCSRLMYD---CC-TGSCRS--GKC^*	2.2 > 2.1	Olivera et al., 1987; Kim et al., 1995; Nielsen et al., 1999a
	MVIIB	P	---CKGKGASCHRTSYD---CC-TGSCN--RGKC	N.D.	Olivera et al., 1987
	MVIIC	P	---CKGKGAPCRKTMYD---CC-SGSC-GRRGKC^*	2.1 > 2.2	Hillyard et al., 1992; Nielsen et al., 1999a
	MVIID	P	---CQGRGASCRKTMYN---CC-SGSCN--RGRC^*	2.1 ≫ 2.2	Haack et al., 1993; Monje et al., 1993; Gandía et al., 1997
C. pennaceus	PnVIA	M	--GCLEVDYFCGIPFANNGLCC-SGNCVFV---CTPQ	Molluscan N-type	Kits et al., 1996
	PnVIB	M	DDDCEPPGNFCGMIKIGPP-CC-SGWCFFA---CA	Molluscan N-type	Kits et al., 1996
C. pulicarius	PuIA	V	-RDCRPVGQYCGIPYEHNWRCC-SQLCAII---CVS	N.D.	Zhao and Huang, 2000
	PuIIA	V	--TCNTPTQYCTLHRH----CC-SLYCHKTIHACA	N.D.	Zhao and Huang, 2000
C. radiatus	RVIA	P	---CKPOGSOCRVSSYN---CC--SSCKSYNKKCG	2.2	Abbott and Litzinger, 1994
C. striatus	SO3	P	---CKAAGKPCSRIAYN---CC-TGSCRS--GKC^*	Na_v ∼ K_v ∼ 2.2 > 2.1 > 2.3	Lu et al., 1999; Li et al., 2003b; Wen et al., 2005
	SO4	P	ATDCIEAGNYCGPTVMKI--CC--GFCSPYSKICMNYPKN	N.D.	Lu et al., 1999
	SO5	P	STSCMEAGSYCGSTTRI---CC--GYCAYFGKKCIDYPSN	N.D.	Lu et al., 1999
	SVIA	P	---CRSSGSOCGVTSI----CC-GR-C-Y-RGKCT^*	2.2 > 2.1	Ramilo et al., 1992
	SVIB	P	---CKLKGQSCRKTSYD---CC-SGSCGRS-GKC^*	2.1 > 2.2	Ramilo et al., 1992; Woppmann et al., 1994; Nadasdi et al., 1995
C. tulipa	TVIA	P	---CLSOGSSCSOTSYN---CC--RSCNOYSRKC	2.2 > 2.1	Chung et al., 1995; Wang et al., 1998
C. textile	TxO1	M	---CLDAGEVCDIFFPT---CC--GYCILLF--CA	N.D.	Lu et al., 1999
	TxO2	M	---CYDSGTSCNTGNQ----CC-SGWCIFV---CL	N.D.	Lu et al., 1999
	TxO3	M	---CYDGGTSCDSGIQ----CC-SGWCIFV---CF	N.D.	Lu et al., 1999
	TxO4	M	-YDCEPPGNFCGMIKIGPP-CC-SGWCFFA---CA	N.D.	Lu et al., 1999
	TxO5	M	---CVPYEGPCNWLTQN---CC-DATCVVFW--CL	N.D.	Lu et al., 1999
	TxO6	M	-NYCQEKWDYCPVPFLGSRYCCDGLFCTLFF--CA	N.D.	Lu et al., 1999
	TxVII	M	---CKQADEPCDVFSLD---CC-TGICLGV---CMW	Molluscan L-type	Fainzilber et al., 1996

P, fish; M, molluscs; V, worms;
↵* , C-terminal amidation; N.D., not determined.