TABLE 3

Effect of acutely administered 5-HT or serotonergic agonist on blood pressure and heart rate in a variety of species

Leftmost column list species or agonist, status of model consciousness, surgical or pharmacological agents on board during experimentation.

5-HT or Agonist and SpeciesSite of AdministrationDoseEffect on Blood PressureEffect on Heart RateTime PointReference
5-HT
    Rat, consciousIV2 μg/ratDecreaseDecreaseMinutesCallera et al., 2005
    Rat, conscious (female)SC2 mg/kgDecreaseMinutesBarney et al., 1981
    Rat, consciousICV<10 nmolIncreaseIncreaseMinutesDedeoğlu and Fisher, 1991
    Rat, consciousICV>10 nmolIncreaseDecreaseMinutesDedeoğlu and Fisher, 1991
    Rat, consciousICV4 nmol/kgIncreaseDecreaseMinutesAnderson et al., 1996
    Rat, consciousICV10 μgIncreaseDecreaseMinutesSaydoff et al., 1996
    Rat, vagotomized and pithed, ketanserinIV10−9–10−5 mol/kgDecreaseTerrón, 1997
    Rat, vagotomized, anesthetized, ritanserinIV1–10 μg · kg−1 · min−1DecreaseMinutesDe Vries et al., 1999
    Rat, anesthetized, vagosympathecto-mized, ketanserinIV1–30 μg/kgDecreaseMinutesCenturión et al., 2004
    Rat, pithedIV5–20 μg/kgIncreaseMinutesCavero et al., 1981
    Rat, syrosingopine and mianserinIV20 μg/kgDecreaseMinutesCavero et al., 1981
    Rat, anesthetizedIR, IMes1–3 μg/minIncreaseIncreaseMinutesJanssen et al., 1989
    Rat, anesthetizedICV20 μgIncreaseDecrease5 minMontes and Johnson, 1990
    Rat, anesthetizedICV20 μgDecreaseDecrease10 minMontes and Johnson, 1990
    Rat, anesthetizedICV40, 120 nmol/kgIncreaseDecreaseMinutesAnderson et al., 1992
    Rat, anesthetizedRVLM5–50 nmolDecreaseDecreaseMinutesKey and Wigfield, 1992
    Cat, anesthetizedFourth ventricle20–640 nmol/kgDecreaseDecreaseMinutesShepheard et al., 1994
    Dog, anesthetizedIV8 μg · kg−1 · min−1DecreaseIncreaseMinutes-hoursCarlson et al., 1967.
    Dog, anesthetizedIV20 μg · kg−1 · min−1DecreaseIncreaseMinutesMartinez and Lokhandwala, 1980
    Calf, metrenperoneIV0.05 mg · kg−1 · min−1DecreaseDecrease, then increaseMinutesLinden et al., 1999
    Human, consciousIV2–4 μg · kg−1 · min−1VariableMinutes–hoursCarlson et al., 1967
    Human, consciousIV20 nmol · kg−1 · min−1No ChangeNo ChangeMinutesHansen et al., 2008
    Human, consciousIL2.5–250 nmolNo ChangeNo ChangeMinutesHansen et al., 2008
    Human, consciousIA (forearm)10–80 ng · kg−1 · min−1No changeNo changeMinutesBlauw et al., 1988
8-OH-DPAT
    Rat, anesthetizedIV8–128 μg/kgDecreaseDecreaseMinutes-hoursFozard et al., 1987
    Rat, anesthetizedIV1 mg/kgDecreaseDecreaseMinutesHelke et al., 1993
    Rat, consciousIP0.05–0.25 mg/kgDecreaseMinutesvan den Buuse and Wegener, 2005
    Rat, conscious, hemorrhagedICV, IV48 nmol/kgIncreaseMinutesScrogin, 2003
    Rat, conscious, hemorrhagedIV30 nmol/kgIncreaseMinutesTiniakov et al., 2007
    Rat, consciousICV<10 nmolIncreaseIncreaseMinutesDedeoğlu and Fisher, 1991
    Rat, consciousICV>10 nmolDecreaseDecreaseMinutesDedeoğlu and Fisher, 1991
    Rat, hemorrhagedICV10 nmolIncreaseIncreaseMinutesJochem et al., 2009
    Rat, anesthetizedVentral medulla0.1 μg/0.1 μlDecreaseDecreaseMinutesValenta and Singer, 1990
    Rat, anesthetizedICV3 nmol/kgIncreaseIncreaseMinutesAnderson et al., 1992
    Rat, anesthetizedVentral medulla20–50 ngDecreaseDecreaseMinutesHelke et al., 1993
    Rabbit, hypovolemic consciousFourth ventricle10–30 nmolIncreaseMinutesEvans et al., 1993
    Cat, anesthetizedIV1–100 μg/kgDecreaseDecreaseMinutesRamage and Fozard, 1987
    Cat, anesthetizedFourth ventricle2.5–40 nmol/kgDecreaseDecreaseMinutesShepheard et al, 1994
    PigIA0.3–10 μg · kg−1 · min−1NoneDecreaseMinutesBom et al., 1989
    DogIV10–300 μg/kgDecreaseNo changeMinutesDabiré et al., 1990
    DogVA0–3 μg/kgDecreaseDecreaseMinutesDabiré et al., 1990
    DogVLPA0.2 μg/siteDecreaseDecreaseDabiré et al., 1990
Buspirone
    Rat, consciousIP0.1/0.5 mg/kgDecrease/increaseMinutesvan den Buuse and Wegener, 2005
5-CT
    Rat, anesthetized, vagotomized. ketanserinIV0.01–0.3 μg/kgDecreaseMinutesCenturión et al, 2004
    Rat, vagotomized, pithed, ketanserinIV10−11-10−7 mol/kgDecreaseMinutesTerrón, 1997
    Rat, anesthetizedICV3 nmol/kgIncreaseIncreaseMinutesAnderson et al., 1992
    Cat, anesthetizedFourth ventricle2.5–40 nmol/kgDecreaseNo changeMinutesShepheard et al, 1994
DP-5-CT
    Rat, anesthetizedICV3 nmol/kgIncreaseIncreaseMinutesAnderson et al., 1992
    Cat, anesthetizedFourth ventricle2.5–40 nmol/kgDecreaseDecreaseMinutesShepheard et al., 1994
Rizatriptan
    Rat, anesthetizedIV0.63–2500 μg/kgDecreaseDecreaseMinutesPagniez et al., 1998
Sumatriptan
    Rat, anesthetizedIV0.63–2500 μg/kgDecreaseDecreaseMinutesPagniez et al., 1998
    Cat, anesthetizedFourth ventricle10–160 nmol/kgDecreaseNo changeMinutesShepheard et al., 1994
α-Methyl-5-HT
    RatIV3–30 μgIncreaseMinutesDalton et al., 1986
5-Methoxytryptamine
    Rat, vagotomized, pithed, ketanserinIV10−9–10−5 mol/kgDecreaseMinutesTerrón, 1997
DOI
    Rat, anesthetizedICV40, 120 nmol/kgIncreaseDecreaseMinutesAnderson et al., 1992
    Rat, anesthetizedIntra-NTS0.05–1 pmolDecreaseDecreaseMinutesComet et al., 2007
    Rat, anesthetizedICV2 μmol/kgIncreaseIncreaseMinutesKnowles and Ramage, 1999
DOB
    Rat, anesthetizedIntra-NTS0.025–0.5 pmolDecreaseDecreaseMinutesMerahi and Laguzzi, 1995
m-CPBG
    Rat, anesthetizedThird ventricle80–320 nmolDecreaseNo changeMinutesFerreira et al., 2004
2-Methyl-5-HT
    Rat, anesthetizedIV3–30 μgDecreaseDecreaseMinutesDalton et al., 1986
m-CPP
    Rat, anesthetizedThird ventricle80–320 nmolIncreaseDecrease then increase≤30 minFerreira et al., 2005
Quipazine
    Rat, anesthetizedICV2 μmol/kgIncreaseIncreaseMinutesKnowles and Ramage, 1999
5-HTP
    Rat, consciousIV2–40 mg · kg−1 · h−1Decrease24 hEchizen and Freed, 1982
    Cat, anesthetizedIV5–10 mg/kgDecreaseHoursFlórez and Armijo, 1974
Tryptophan
    Rat, SHR, consciousIP1–100 mg/kgDecreaseHoursSved et al., 1982
    Rat, consciousIV2–40 mg · kg−1 · h−1No change24 hEchizen and Freed, 1982

  • 5-HTP, 5-hydroxytryptophan; DOB, 2,5-dimethoxy-4-bromoamphetamine hydrochloride; DOI, (±)-2,5-dimethoxy-4-iodoamphetamine; DP-5-CT, dipropyl-5-carboxamidotryptamine; IA, intraarterial; ICV, intracerebroventricular; IL, intraluminal (intestinal); IMes, intramesenteric artery; IP, intraperitoneal; IR, intrarenal artery; IV, intravenous; m-CPBG, m-chlorophenylbiguanidine; m-CPP, 1-(3-chlorophenyl)piperazine hydrochloride; VA, vertebral artery; VLPA, ventrolateral pressor area.