5-HT or Agonist and Species | Site of Administration | Dose | Effect on Blood Pressure | Effect on Heart Rate | Time Point | Reference |
---|---|---|---|---|---|---|
5-HT | ||||||
Rat, conscious | IV | 2 μg/rat | Decrease | Decrease | Minutes | Callera et al., 2005 |
Rat, conscious (female) | SC | 2 mg/kg | Decrease | Minutes | Barney et al., 1981 | |
Rat, conscious | ICV | <10 nmol | Increase | Increase | Minutes | Dedeoğlu and Fisher, 1991 |
Rat, conscious | ICV | >10 nmol | Increase | Decrease | Minutes | Dedeoğlu and Fisher, 1991 |
Rat, conscious | ICV | 4 nmol/kg | Increase | Decrease | Minutes | Anderson et al., 1996 |
Rat, conscious | ICV | 10 μg | Increase | Decrease | Minutes | Saydoff et al., 1996 |
Rat, vagotomized and pithed, ketanserin | IV | 10−9–10−5 mol/kg | Decrease | Terrón, 1997 | ||
Rat, vagotomized, anesthetized, ritanserin | IV | 1–10 μg · kg−1 · min−1 | Decrease | Minutes | De Vries et al., 1999 | |
Rat, anesthetized, vagosympathecto-mized, ketanserin | IV | 1–30 μg/kg | Decrease | Minutes | Centurión et al., 2004 | |
Rat, pithed | IV | 5–20 μg/kg | Increase | Minutes | Cavero et al., 1981 | |
Rat, syrosingopine and mianserin | IV | 20 μg/kg | Decrease | Minutes | Cavero et al., 1981 | |
Rat, anesthetized | IR, IMes | 1–3 μg/min | Increase | Increase | Minutes | Janssen et al., 1989 |
Rat, anesthetized | ICV | 20 μg | Increase | Decrease | 5 min | Montes and Johnson, 1990 |
Rat, anesthetized | ICV | 20 μg | Decrease | Decrease | 10 min | Montes and Johnson, 1990 |
Rat, anesthetized | ICV | 40, 120 nmol/kg | Increase | Decrease | Minutes | Anderson et al., 1992 |
Rat, anesthetized | RVLM | 5–50 nmol | Decrease | Decrease | Minutes | Key and Wigfield, 1992 |
Cat, anesthetized | Fourth ventricle | 20–640 nmol/kg | Decrease | Decrease | Minutes | Shepheard et al., 1994 |
Dog, anesthetized | IV | 8 μg · kg−1 · min−1 | Decrease | Increase | Minutes-hours | Carlson et al., 1967. |
Dog, anesthetized | IV | 20 μg · kg−1 · min−1 | Decrease | Increase | Minutes | Martinez and Lokhandwala, 1980 |
Calf, metrenperone | IV | 0.05 mg · kg−1 · min−1 | Decrease | Decrease, then increase | Minutes | Linden et al., 1999 |
Human, conscious | IV | 2–4 μg · kg−1 · min−1 | Variable | Minutes–hours | Carlson et al., 1967 | |
Human, conscious | IV | 20 nmol · kg−1 · min−1 | No Change | No Change | Minutes | Hansen et al., 2008 |
Human, conscious | IL | 2.5–250 nmol | No Change | No Change | Minutes | Hansen et al., 2008 |
Human, conscious | IA (forearm) | 10–80 ng · kg−1 · min−1 | No change | No change | Minutes | Blauw et al., 1988 |
8-OH-DPAT | ||||||
Rat, anesthetized | IV | 8–128 μg/kg | Decrease | Decrease | Minutes-hours | Fozard et al., 1987 |
Rat, anesthetized | IV | 1 mg/kg | Decrease | Decrease | Minutes | Helke et al., 1993 |
Rat, conscious | IP | 0.05–0.25 mg/kg | Decrease | Minutes | van den Buuse and Wegener, 2005 | |
Rat, conscious, hemorrhaged | ICV, IV | 48 nmol/kg | Increase | Minutes | Scrogin, 2003 | |
Rat, conscious, hemorrhaged | IV | 30 nmol/kg | Increase | Minutes | Tiniakov et al., 2007 | |
Rat, conscious | ICV | <10 nmol | Increase | Increase | Minutes | Dedeoğlu and Fisher, 1991 |
Rat, conscious | ICV | >10 nmol | Decrease | Decrease | Minutes | Dedeoğlu and Fisher, 1991 |
Rat, hemorrhaged | ICV | 10 nmol | Increase | Increase | Minutes | Jochem et al., 2009 |
Rat, anesthetized | Ventral medulla | 0.1 μg/0.1 μl | Decrease | Decrease | Minutes | Valenta and Singer, 1990 |
Rat, anesthetized | ICV | 3 nmol/kg | Increase | Increase | Minutes | Anderson et al., 1992 |
Rat, anesthetized | Ventral medulla | 20–50 ng | Decrease | Decrease | Minutes | Helke et al., 1993 |
Rabbit, hypovolemic conscious | Fourth ventricle | 10–30 nmol | Increase | Minutes | Evans et al., 1993 | |
Cat, anesthetized | IV | 1–100 μg/kg | Decrease | Decrease | Minutes | Ramage and Fozard, 1987 |
Cat, anesthetized | Fourth ventricle | 2.5–40 nmol/kg | Decrease | Decrease | Minutes | Shepheard et al, 1994 |
Pig | IA | 0.3–10 μg · kg−1 · min−1 | None | Decrease | Minutes | Bom et al., 1989 |
Dog | IV | 10–300 μg/kg | Decrease | No change | Minutes | Dabiré et al., 1990 |
Dog | VA | 0–3 μg/kg | Decrease | Decrease | Minutes | Dabiré et al., 1990 |
Dog | VLPA | 0.2 μg/site | Decrease | Decrease | Dabiré et al., 1990 | |
Buspirone | ||||||
Rat, conscious | IP | 0.1/0.5 mg/kg | Decrease/increase | Minutes | van den Buuse and Wegener, 2005 | |
5-CT | ||||||
Rat, anesthetized, vagotomized. ketanserin | IV | 0.01–0.3 μg/kg | Decrease | Minutes | Centurión et al, 2004 | |
Rat, vagotomized, pithed, ketanserin | IV | 10−11-10−7 mol/kg | Decrease | Minutes | Terrón, 1997 | |
Rat, anesthetized | ICV | 3 nmol/kg | Increase | Increase | Minutes | Anderson et al., 1992 |
Cat, anesthetized | Fourth ventricle | 2.5–40 nmol/kg | Decrease | No change | Minutes | Shepheard et al, 1994 |
DP-5-CT | ||||||
Rat, anesthetized | ICV | 3 nmol/kg | Increase | Increase | Minutes | Anderson et al., 1992 |
Cat, anesthetized | Fourth ventricle | 2.5–40 nmol/kg | Decrease | Decrease | Minutes | Shepheard et al., 1994 |
Rizatriptan | ||||||
Rat, anesthetized | IV | 0.63–2500 μg/kg | Decrease | Decrease | Minutes | Pagniez et al., 1998 |
Sumatriptan | ||||||
Rat, anesthetized | IV | 0.63–2500 μg/kg | Decrease | Decrease | Minutes | Pagniez et al., 1998 |
Cat, anesthetized | Fourth ventricle | 10–160 nmol/kg | Decrease | No change | Minutes | Shepheard et al., 1994 |
α-Methyl-5-HT | ||||||
Rat | IV | 3–30 μg | Increase | Minutes | Dalton et al., 1986 | |
5-Methoxytryptamine | ||||||
Rat, vagotomized, pithed, ketanserin | IV | 10−9–10−5 mol/kg | Decrease | Minutes | Terrón, 1997 | |
DOI | ||||||
Rat, anesthetized | ICV | 40, 120 nmol/kg | Increase | Decrease | Minutes | Anderson et al., 1992 |
Rat, anesthetized | Intra-NTS | 0.05–1 pmol | Decrease | Decrease | Minutes | Comet et al., 2007 |
Rat, anesthetized | ICV | 2 μmol/kg | Increase | Increase | Minutes | Knowles and Ramage, 1999 |
DOB | ||||||
Rat, anesthetized | Intra-NTS | 0.025–0.5 pmol | Decrease | Decrease | Minutes | Merahi and Laguzzi, 1995 |
m-CPBG | ||||||
Rat, anesthetized | Third ventricle | 80–320 nmol | Decrease | No change | Minutes | Ferreira et al., 2004 |
2-Methyl-5-HT | ||||||
Rat, anesthetized | IV | 3–30 μg | Decrease | Decrease | Minutes | Dalton et al., 1986 |
m-CPP | ||||||
Rat, anesthetized | Third ventricle | 80–320 nmol | Increase | Decrease then increase | ≤30 min | Ferreira et al., 2005 |
Quipazine | ||||||
Rat, anesthetized | ICV | 2 μmol/kg | Increase | Increase | Minutes | Knowles and Ramage, 1999 |
5-HTP | ||||||
Rat, conscious | IV | 2–40 mg · kg−1 · h−1 | Decrease | 24 h | Echizen and Freed, 1982 | |
Cat, anesthetized | IV | 5–10 mg/kg | Decrease | Hours | Flórez and Armijo, 1974 | |
Tryptophan | ||||||
Rat, SHR, conscious | IP | 1–100 mg/kg | Decrease | Hours | Sved et al., 1982 | |
Rat, conscious | IV | 2–40 mg · kg−1 · h−1 | No change | 24 h | Echizen and Freed, 1982 |
5-HTP, 5-hydroxytryptophan; DOB, 2,5-dimethoxy-4-bromoamphetamine hydrochloride; DOI, (±)-2,5-dimethoxy-4-iodoamphetamine; DP-5-CT, dipropyl-5-carboxamidotryptamine; IA, intraarterial; ICV, intracerebroventricular; IL, intraluminal (intestinal); IMes, intramesenteric artery; IP, intraperitoneal; IR, intrarenal artery; IV, intravenous; m-CPBG, m-chlorophenylbiguanidine; m-CPP, 1-(3-chlorophenyl)piperazine hydrochloride; VA, vertebral artery; VLPA, ventrolateral pressor area.