Alosetron | | | |
0.25 (n = 8) or 4 mg (n = 8) twice daily for 7 days | Distension of colon in 16 patients with IBS. | Effect on mechanical stimulation at both the first sensation threshold and the perception of abdominal pain. | Delvaux et al. (1998) |
1, 2, or 4 mg twice daily for 3 weeks | Rectosigmoid distension and PET scan in 37 patients with IBS. | No effects on rectal distension. Reduced regional cerebral blood flow in various structures relating to the brains pain matrix. | Mayer et al. (2002) |
1 or 4 mg twice daily for 4 weeks | Rectal balloon distension in 25 patients with IBS. | No significant effects. | Thumshirn et al. (2000) |
Granisetron | | | |
1 mg i.m. | Pressure pain threshold over the masseter muscle in 18 patients with fibromyalgia. | No significant effect. | Ernberg et al. (2003) |
40 or 160 μg/kg i.v. | Threshold volumes for sensation of gas, desire to defecate, urgency, and discomfort in 12 patients with IBS. | Significant difference for all sensations at the higher dose level. | Prior and Read (1993) |
Ondansetron | | | |
0.15 mg/kg single i.v. | In 12 patients with IBS, the stomach and the rectum were distended, and somatic pain was evaluated by immersion of a hand in cold water. | No significant effect. | Zighelboim et al. (1995) |