TABLE 5

Effect of serotonergic compounds on blood pressure of different species

CompoundSpeciesEffect on Blood PressureDoseReference
TCAs
    ImipramineHumanOrthostatic hypotension1–5 g/kg/dayGiardina et al., 1985
    ImipramineHumanOrthostatic hypotension100 mg/dayThayssen et al., 1981
    ImipramineHumanOrthostatic hypotension∼225 mg/dayGlassman et al., 1979
    ImipramineRabbitDecrease29 mg/kgHughes and Radwan, 1979
    ImipramineDogDecrease0.1–10 mg/kgKato et al., 1974
    ImipramineDogDecrease1–10 mg/kgYokota et al., 1987
    ImipramineHumanOrthostatic hypotension200 mg/dayGuelfi et al., 1983
    ImipramineDogDecrease0.5 mg · kg−1 · min−1Lindbom et al., 1982
    NortriptylineHumanOrthostatic hypotension0.5–3.5 mg/kg/dayGiardina et al., 1985
    NortriptylineHumanNo change40 mg/dayThayssen et al., 1981
    AmitriptylineRabbitDecrease15 mg/kgHughes and Radwan, 1979
    AmitriptylineDogDecrease0–20 mg/kgLindbom et al., 1982
    AmitriptylineDogDecrease1–10 mg/kgYokota et al., 1987
    AmitriptylineDogDecrease0.1–10 mg/kgKato et al., 1974
    AmitriptylineHumanDecrease25 mg/dayOgura et al., 1983
    AmitriptylineHumanNo change75 mg/dayPenttilä et al., 2001
    MaprotilineRabbitDecrease34 mg/kgHughes and Radwan, 1979
    ClomipramineDogDecrease1–10 mg/kgYokota et al., 1987
    ClomipramineHumanOrthosatic hypotension150 mg/dayChristensen et al., 1985
    ClomipramineDogDecrease0–20 mg/kgLindbom et al., 1982
    DesmethylimipramineHumanIncrease100 mgRoss et al,. 1983
    DesipramineHumanNo change100 mg/dayChalon et al., 2003
MAO Inhibitors
    RasagilineRatNo change0.2–1 mg/kgFinberg et al., 2006
    RasagilineRatNo change1 mg/kgAbassi et al., 2004
    RasagilineRatDecrease10 mg/kgAbassi et al., 2004
    SelegilineRatNo change1–5 mg/kgFinberg et al., 2006
    SelegilineHumanOrthostatic hypotension10 mg/dayTurkka et al., 1997
    SelegilineRatNo change1 mg/kgAbassi et al., 2004
    SelegilineRatDecrease10 mg/kgAbassi et al., 2004
    L-DeprenylRatNo change5 mg/kgStevens et al., 1998
    L-DeprenylRatIncrease25 μg/100 gKerecsen and Bunag, 1989
    ClorgylineRatNo change2 mg/kgFinberg et al., 2006
    ClorgylineRatNo change/decrease25 μg/100gKerecsen and Bunag, 1989
    ClorgylineHumanDecrease28 mg/dayMurphy et al., 1979
    HarmalineRatDecrease20 mg/kgMarwood et al., 1985
    PargylineRatDecrease100 mg/kgMarwood et al., 1985
    PargylineRatDecrease10 mg/kgFuentes et al., 1979
    PargylineHumanDecrease87 mg/dayMurphy et al., 1979
    TranylcypromineRatDecrease10 mg/kgMarwood et al., 1985
    TranylcypromineRatDecrease5 mg/kgAshkenazi et al., 1983
    TranylcypromineHumanOrthostatic hypotension20–100 mg/dayNolen et al., 1993
    TranylcypromineRatIncrease25 mg/kgFinberg et al., 2006
    IsoniazidRatDecrease30–300 mg/kgVidrio et al., 2000
    BrofaromineHumanOrthostatic hypotension50–250 mg/dayNolen et al., 1993
SSRIs
    CitalopramHumanNo change40 mg/dayChristensen et al., 1985
    CitalopramHumanNo change40–60 mg/dayPedersen et al., 1982
    CitalopramHumanNo change20 mg/dayPenttilä et al., 2001
    FluvoxamineHumanNo change300 mg/dayGuelfi et al., 1983
    FluoxetineRatIncrease10–50 μg i.c.v.Lazartigues et al., 2000
    FluoxetineRatDecrease10 mg/kgSved et al., 1982
    FluoxetineHumanIncrease20 mg/dayAmsterdam et al., 1999
    ParoxetineDogIncrease/ Decrease0.1–10 mg/kgYokota et al., 1987
    SertralineHuman, adolescentNo changeUp to 200 mg/dayWilens et al., 1999
    SertralineHumanNo changeUp to 400 mg/daySaletu et al., 1986
    ZimeldineDogDecrease1–20 mg/kgLindbom et al., 1982
    ZimeldineHumanNo change100 mg/daySaletu et al., 1986
SNRIs
    MilnacipranHumanIncrease0.2–0.8 mg/kgCaron et al., 1993
    VenlafaxineHumanIncrease75–225 mg/dayPerahia et al., 2008
    VenlafaxineHumanDecrease75–225 mg/dayAlexandrino-Silva et al., 2008
    VenlafaxineHumanIncrease225–525 mg/dayMbaya et al., 2007
    DuloxetineRatDecrease30 mg/dayChudasama and Bhatt, 2009
    DuloxetineHumanIncrease120–400 mg/dayDerby et al., 2007
    DuloxetineHumanNo change60–120 mg/dayPerahia et al., 2008
    DuloxetineHumanNo change40–120 mg/dayBailey et al., 2006
    DuloxetineHumanIncrease80 mg/dayChalon et al., 2003
    SibutramineHumanDecrease10–15 mg/daySharma et al., 2009
    SibutramineHumanBasal increase, decrease in sympathetic stimulation15 mg/dayBirkenfeld et al., 2005
    SibutramineRatNo change5 mg/dayChudasama and Bhatt, 2009
    SibutramineHumanDecrease10–15 mg/dayGaciong and Placha, 2005
    SibutramineHumanIncrease5–20 mg/dayMcMahon et al., 2000