TABLE 2

Pharmacological treatments for premature ejaculation

IELT is expressed as fold increase compared with placebo. [Adapted from Althof SE, Abdo CH, Dean J, Hackett G, McCabe M, McMahon CG, Rosen RC, Sadovsky R, Waldinger M, Becher E, et al. (2010) International Society for Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation. J Sex Med 7:2947–2969. Copyright © 2010 John Wiley & Sons. Used with permission.]

DrugRegimenDoseIELT IncreaseReferenceMost Common Side EffectsStatus
mgfold
Oral
    DapoxetineOn demand30–602.5–3Pryor et al., 2006; McMahon et al., 2010Nausea, headacheApproved in various countries
    ParoxetineDaily10–408Waldinger et al., 1994Fatigue, yawning, nausea, diarrhea, decreased libido, erectile dysfunctionOff label
    ClomipramineDaily12.5–506Goodman, 1980; Althof et al., 1995Off label
    SertralineDaily50–2005McMahon, 1998Off label
    FluoxetineDaily20–405Kara et al., 1996
    CitalopramDaily20–402Atmaca et al., 2002Off label
    ParoxetineDaily for 30 days then on demand10–4011.6McMahon and Touma, 1999Off label
    ParoxetineOn demand10–401.4Waldinger et al., 2004Off label
    ClomipramineOn demand12.5–504Waldinger et al., 2004Off label
Topical
    Lidocaine/prilocaineOn demand2.5%/2.5%4–6Busato and Galindo, 2004Penile numbness, partner genital numbnessOff label