Superfamily | Cysteine Framework | Family | Species | Clades | Diet | PTMs |
---|---|---|---|---|---|---|
A | I, II, IV, XIV | α, κ, ρ | 43 | E, I, II, III, V, VI, VII, X, XII, XIV, XV, XVII | V, M, P | O, *, γ, G, Z, Ys |
D | XX | α | 6 | XII | V | O, γ |
I1 | VI/VII, XI | ι | 11 | E, I, V, X, XIV, XVII | V, M, P | O, BrW, *, D, γ |
I2 | XI, XII | κ | 17 | I, V, VI, X, XII, XIII, XVII | V, M, P | O, *, γ |
I3 | VI/VII, XI | 3 | XIV | V | ||
J | XIV | κ | 2 | IX | V | * |
L | XIV | α | 2 | E | V, P | |
M | III, IV, VI/VII, IX, XVI | α, ι, κ, μ | 28 | E, I, II, III, IV, V, VI, VII, X, XII, XIV, XVI, XVII | V, M, P | O, *, D |
O1 | VI/VII, XII | δ, γ, κ, μO, ω | 53 | E, I, II, III, V, VI, VII, IX, X, XI, XII, XIII, XIV, XV, XVI, XVII | V, M, P | O, BrW, *, γ |
O2 | VI/VII, XV | γ | 15 | I, V, VI, VII, X, XII, XIII, XIV, XVI | V, M, P | O, BrW, *, γ |
O3 | VI/VII | 6 | V, VII, XIV, XVI | V, M, P | ||
P | IX | 6 | V, X, XVII | V, M | *, γ | |
S | VIII | α, σ | 6 | I, II, V, XIV | V, M, P | O, BrW, *, γ |
T | I, V, X, XVI | χ, ε, μ | 24 | E, II, III, V, VI, VII, X, XII, XIII, XIV, XVI, XVII | V, M, P | O, BrW, *, γ, G, Z |
V | XV | 2 | XIII | V | * | |
Y | XVII | 1 | XIV | V | O |
E, early clade; P, fish; M, molluscs; V, worms;
↵* , C-terminal amidation; O, hydroproline; BrW, bromotryptophane; D, d-amino acid; γ, γ-carboxyglutamate; γ-Val, γ-hydroxyvaline; G, glycosylation; Z, pyroglutamate; Ys, sulfotyrosine.