TABLE 1

NSAIDs and acetaminophen

Drug and DoseMethodCommentReferences
Acetaminophen
    1 g oralElectrical pulp testing in 20 patients with dental pain.Pain threshold increased.Carnes et al. (1998)
Diclofenac
    75 mg oralElectrical stimulation at or distant from the incision were studied in 120 patients who had elective cesarean deliver.No significant effect of NSAID alone, but increases in sensation and pain tolerance thresholds were seen for the combination tramadol plus diclofenac.Wilder-Smith et al. (2003)
Ibuprofen
    Dolgit cream (5%), 3 g 3× dailyPressure stimulation of finger joints in 11 patients with rheumatoid arthritis.Pain detection threshold did not increase but a significant difference in pressure pain tolerance threshold was found.Arendt-Nielsen et al. (1994)
Naproxen sodium
    220 mg oralElectrical pulp testing in 20 patients with dental pain.No significant effect.Carnes et al. (1998)