Examples of stimuli responsive strategies
| Response to | Target | Examples |
|---|---|---|
| pH | Acidic compartments found at pathological tissues (tumor sites) or within cells in the endosomes. | Gao et al., 2005; Bae et al., 2007; Cohen et al., 2008, 2009; Lee et al., 2008 |
| Thermal | Heat applied external or from physiologically changes | De et al., 2008; Rahimi et al., 2008; Peng et al., 2011 |
| Light | Externally applied light | Suzuki and Tanaka, 1990; Goodwin et al., 2005; Jiang et al., 2006; Fomina et al., 2010 |
| Redox | Regions where reactive oxidative and reductive species are abundant (inflammation and tumor sites) | Napoli et al., 2004; Rehor et al., 2005; Reddy et al., 2006; Wilson et al., 2010; Mahmoud et al., 2011 |
| Enzyme | Regions of high protease expression such as cancerous tissue | Olson et al., 2009; Andresen et al., 2010; Whitney et al., 2010; van Duijnhoven et al., 2011; Wong et al., 2011 |