TABLE 5

Effects of prostacyclin analogs on representative vascular preparations

Species	Blood Vessel	Agonist and Dose	Receptor Involved	Effect	Reference
Human	Pulmonary arteries and veins precontracted with norepinephrine	PGI₂ (0.1 nM–10 μM)	IP (Arteries) EP1, IP (Veins)	Dose-dependent relaxation Reduced relaxation	Norel et al., 2004
Monkey	Cerebral arteries precontracted with 5-hydroxytryptamine	Isocarbacyclin 0.1 nM–10 μM ≥ 1 μM	IP TP, IP	Dose-dependent relaxation Transient contraction followed by sustained relaxation	Kawai and Ohhashi, 1994
Piglets	Saphenous vein precontracted with phenylephrine	AFP-07 (0.3–14 nM)	EP4, IP	Relaxation	Jones and Chan, 2001
Guinea pig	Aorta precontracted with phenylephrine	Iloprost (1–50 nM) Carbacyclin (3 to 43 nM)	IP	Relaxation	Jones and Chan, 2001
Guinea pig	Aorta precontracted with phenylephrine	Iloprost (1–50 nM) Carbacyclin (3 to 43 nM)	EP3, IP	Contraction followed by relaxation at higher doses	Jones and Chan, 2001
Rabbit	Mesenteric artery precontracted with phenylephrine	Carbacyclin Initial 1–14 nM then higher	EP3, IP	Contraction followed by relaxation at higher doses	Jones and Chan, 2001
Rat	Aorta precontracted with norepinephrine	PGI₂, Carbacyclin			Williams et al., 1994
		≤1 μM	IP	Relaxation
		>1 μM	TP	↓ PGI₂-induced relaxation