Species | Blood Vessel | Agonist and Dose | Receptor Involved | Effect | Reference |
---|---|---|---|---|---|
Human | Pulmonary arteries and veins precontracted with norepinephrine | PGI2 (0.1 nM–10 μM) | IP (Arteries) EP1, IP (Veins) | Dose-dependent relaxation Reduced relaxation | Norel et al., 2004 |
Monkey | Cerebral arteries precontracted with 5-hydroxytryptamine | Isocarbacyclin 0.1 nM–10 μM ≥ 1 μM | IP TP, IP | Dose-dependent relaxation Transient contraction followed by sustained relaxation | Kawai and Ohhashi, 1994 |
Piglets | Saphenous vein precontracted with phenylephrine | AFP-07 (0.3–14 nM) | EP4, IP | Relaxation | Jones and Chan, 2001 |
Guinea pig | Aorta precontracted with phenylephrine | Iloprost (1–50 nM) Carbacyclin (3 to 43 nM) | IP | Relaxation | Jones and Chan, 2001 |
EP3, IP | Contraction followed by relaxation at higher doses | ||||
Rabbit | Mesenteric artery precontracted with phenylephrine | Carbacyclin Initial 1–14 nM then higher | EP3, IP | Contraction followed by relaxation at higher doses | Jones and Chan, 2001 |
Rat | Aorta precontracted with norepinephrine | PGI2, Carbacyclin | Williams et al., 1994 | ||
≤1 μM | IP | Relaxation | |||
>1 μM | TP | ↓ PGI2-induced relaxation |