Table 2

SOs induce cell differentiation in vitro

Cells Undergoing DifferentiationTriterpenoidCombination(s)References
U937, THP-1 l monocytic leukemia cells; LCDB, NB4 myelocytic leukemia cellsCDDO
CDDO-Im
Deltanoid ILX23-7553
Rexinoid LG100268
TGF-β
Suh et al., 1999; Place et al., 2003
HL-60 granulomonocytic leukemia cells and/or AML primary blastsCDDO-Me
CDDO-Im
CDDO
ATRA
1α,25(OH2)vitamin D3
TGF-β superfamily
Konopleva et al., 2002; Ji et al., 2006; Koschmieder et al., 2007; Tsao et al., 2010
NB4 and MR2 acute promyelocytic leukemia cells and primary APL cellsCDDO
CDDO-Im
ATRAIkeda et al., 2005; Tabe et al., 2007
Neuronal differentiation of PC12 pheochromocytoma cellsCDDONGFSuh et al., 1999
Adipogenic differentiation of 3T3L1 fibroblastsCDDOLG100268Suh et al., 1999; Wang et al., 2000
Saos-2 osteosarcoma cellsCDDONoneIto et al., 2001
Megakaryocytic differentiation of normal hemopoietic progenitor cells and HEL and TF1 human erythroleukemic cell linesCDDO-ImNonePetronelli et al., 2011
Chondrogenic differentiation of human bone marrow-derived mesenchymal stem cellsCDDO-Im
CDDO-EA
NoneSuh et al., 2012
  • ILX23-7553, 1,25-dihydroxy-16-ene-23-yne vitamin D3.