SOs inhibit proliferation and/or induce apoptosis of cancer cells in vitro
| Cell Type | Triterpenoid | References |
|---|---|---|
| B and T cell leukemias (AML, APL, CML, Sézary syndrome), lymphomas/ mycosis fungoides and plasmacytomas | CDDO CDDO-Me CDDO-Im | Suh et al., 1999, 2003b; Ito et al., 2000; Konopleva et al., 2002, 2004, 2005; Stadheim et al., 2002; Ikeda et al., 2003, 2005; Place et al., 2003; Inoue et al., 2004; Zhang et al., 2004; Han et al., 2006; Ray et al., 2006; Samudio et al., 2006, 2008; Shishodia et al., 2006; Brookes et al., 2007; Koschmieder et al., 2007; Kress et al., 2007; Tabe et al., 2007, 2010; Elsawa et al., 2008; Riccioni et al., 2008; Ahmad et al., 2010; Bernstein et al., 2012 |
| ER-positive and -negative breast cancer | CDDO CDDO-Im CDDO-Me | Suh et al., 1999; Lapillonne et al., 2003; Place et al., 2003; Honda et al., 2004; Hyer et al., 2005; Konopleva et al., 2006; Ling et al., 2007; Liby et al., 2008b; Kim et al., 2011 |
| Ovarian cancer | CDDO CDDO-Me CDDO-Im | Suh et al., 1999; Melichar et al., 2004; Duan et al., 2009; Petronelli et al., 2009b; Gao et al., 2011b |
| Prostate cancer | CDDO CDDO-Me CDDO-Im | Deeb et al., 2007, 2008, 2009, 2010b; Hyer et al., 2008; Vene et al., 2008 |
| NSCLC | CDDO CDDO-Me CDDO-Im CDDO-MA CDDO-EA CDDO-TFEA | Kim et al., 2002; Zou et al., 2004, 2007, 2008; Liby et al., 2006, 2007a, 2009; Yue et al., 2006 |
| Pancreatic cancer | CDDO CDDO-Im CDDO-Me | Suh et al., 1999; Samudio et al., 2005; Deeb et al., 2010a; Jutooru et al., 2010; Liby et al., 2010 |
| Colon cancer | CDDO CDDO-Me CDDO-Im | Chintharlapalli et al., 2005; Gao et al., 2010, 2011a; Townson et al., 2011 |
| Osteosarcoma, chondrosarcoma, liposarcoma, Ewing's sarcoma, chordoma | CDDO CDDO-Me CDDO-Im CDDO-EA CDDO-TFEA | Ito et al., 2001; Alabran et al., 2008; Hughes et al., 2008; Olsen et al., 2010; Ryu et al., 2010a,b; Yang et al., 2010 |
| Multiple myeloma | CDDO CDDO-Im | Chauhan et al., 2004; Ikeda et al., 2004; Liby et al., 2006 |
| Melanoma and other skin cancer cells | CDDO CDDO-Im | Suh et al., 1999; Hail et al., 2004; Townson et al., 2011 |
| Glioblastoma and neuroblastoma | CDDO CDDO-Me CDDO-Im | Gao et al., 2007; Alabran et al., 2008 |
CML, chronic myelogenous leukemia; NSCLC, non–small-cell lung carcinoma.