Table 3

SOs inhibit proliferation and/or induce apoptosis of cancer cells in vitro

Cell TypeTriterpenoidReferences
B and T cell leukemias (AML, APL, CML, SĂ©zary syndrome), lymphomas/ mycosis fungoides and plasmacytomasCDDO
CDDO-Me
CDDO-Im
Suh et al., 1999, 2003b; Ito et al., 2000; Konopleva et al., 2002, 2004, 2005; Stadheim et al., 2002; Ikeda et al., 2003, 2005; Place et al., 2003; Inoue et al., 2004; Zhang et al., 2004; Han et al., 2006; Ray et al., 2006; Samudio et al., 2006, 2008; Shishodia et al., 2006; Brookes et al., 2007; Koschmieder et al., 2007; Kress et al., 2007; Tabe et al., 2007, 2010; Elsawa et al., 2008; Riccioni et al., 2008; Ahmad et al., 2010; Bernstein et al., 2012
ER-positive and -negative breast cancerCDDO
CDDO-Im
CDDO-Me
Suh et al., 1999; Lapillonne et al., 2003; Place et al., 2003; Honda et al., 2004; Hyer et al., 2005; Konopleva et al., 2006; Ling et al., 2007; Liby et al., 2008b; Kim et al., 2011
Ovarian cancerCDDO
CDDO-Me
CDDO-Im
Suh et al., 1999; Melichar et al., 2004; Duan et al., 2009; Petronelli et al., 2009b; Gao et al., 2011b
Prostate cancerCDDO
CDDO-Me
CDDO-Im
Deeb et al., 2007, 2008, 2009, 2010b; Hyer et al., 2008; Vene et al., 2008
NSCLCCDDO
CDDO-Me
CDDO-Im
CDDO-MA
CDDO-EA
CDDO-TFEA
Kim et al., 2002; Zou et al., 2004, 2007, 2008; Liby et al., 2006, 2007a, 2009; Yue et al., 2006
Pancreatic cancerCDDO
CDDO-Im
CDDO-Me
Suh et al., 1999; Samudio et al., 2005; Deeb et al., 2010a; Jutooru et al., 2010; Liby et al., 2010
Colon cancerCDDO
CDDO-Me
CDDO-Im
Chintharlapalli et al., 2005; Gao et al., 2010, 2011a; Townson et al., 2011
Osteosarcoma, chondrosarcoma, liposarcoma, Ewing's sarcoma, chordomaCDDO
CDDO-Me
CDDO-Im
CDDO-EA
CDDO-TFEA
Ito et al., 2001; Alabran et al., 2008; Hughes et al., 2008; Olsen et al., 2010; Ryu et al., 2010a,b; Yang et al., 2010
Multiple myelomaCDDO
CDDO-Im
Chauhan et al., 2004; Ikeda et al., 2004; Liby et al., 2006
Melanoma and other skin cancer cellsCDDO
CDDO-Im
Suh et al., 1999; Hail et al., 2004; Townson et al., 2011
Glioblastoma and neuroblastomaCDDO
CDDO-Me
CDDO-Im
Gao et al., 2007; Alabran et al., 2008
  • CML, chronic myelogenous leukemia; NSCLC, non–small-cell lung carcinoma.