TABLE 1

Main peptides derived from the Antennapedia third helix and their properties

All internalized peptides are internalized at 4 and 37°C. Internalization of the d-enantiomer peptides demonstrates an absence of chiral receptors. The addition of one or three proline does not block internalization in spite of the absence of an α-helical structure. In conclusion, internalization requires the appropriate localization of Arg and Trp residues