Table 1

SOs inhibit the production of inflammatory mediators in various cells

TriterpenoidReduced Inflammatory MediatorsCell TypeReference
CDDONO, iNOS, COX-2Peritoneal macrophages, human colon myofibroblastsHonda et al., 1998; Suh et al., 1999
CDDOMMP-1, MMP-13Chondrosarcoma cells, human chondrocytesElliott et al., 2003; Mix et al., 2001
CDDO-ImIL-6Multiple myeloma cellsChauhan et al., 2004
CDDO-MeVEGF, COX-2, MMP-9Human leukemia cellsShishodia et al., 2006
CDDO-ImTNFα, IL-6, Mcp1, Mip2NeutrophilsThimmulappa et al., 2006b
CDDO
CDDO-Me
IL-6, TNFαHuman PBMCsThimmulappa et al., 2007
CDDO-ImSerum IFNγ, TNFαN.A.Osburn et al., 2008
CDDO-MeTNFα, IL-1β, Mip1α, IL-6, IL-12, IL-10Microglia and peritoneal macrophagesTran et al., 2008
CDDOIL-8, IL-1β, IL-6, TNFα, MIP-2, KCPrimary airway epithelia and bronchoalveolar lavageNichols et al., 2009
CDDO-ImTNFα, IL-17, GCSF, IL-23, LIXBronchoalveolar lavage fluidSegal et al., 2010
CDDOTNFαDonor T cellsLi et al., 2010
CDDO-MeIL-12p70, IFN-γ, IL-6, IL-17, IL-23SplenocytesAuletta et al., 2010
CDDO-MeIL-6Pancreatic cancer cellsLiby et al., 2010
CDDOIL-6, MCP-1, COX-2, PGE2Human lung fibroblastsHogan et al., 2011
CDDO-ImIL-6, IL-10, TGF-βPrimary orthotopic breast tumorsLiao et al., 2011
CDDO-TFEAIL-6, IL-17, IFNγ, TNFα, GM-CSFBlood lymphocytes from mice with EAEPareek et al., 2011
CDDO-MeCXCL12, CCL2, MMP-9Primary tumor cells from PyMT miceTran et al., 2012
  • COX, cyclooxygenase; KC, keratinocyte-derived cytokine; GCSF, granulocyte–colony-stimulating factor; LIX, lipopolysaccharide-induced CXC chemokine; GM-CSF, granulocyte macrophage–colony-stimulating factor; EAE, experimental autoimmune encephalomyelitis; PyMT, polyoma middle T.