Gene | Mouse Strain | Normal Growth? | In Vivo Model | Effect of Receptor Deletion | Reference |
---|---|---|---|---|---|
CCR1 | C57Bl/6 | Yes | Analysis of BM and spleen myeloid progenitor cell development . | Defective migration of progenitors to spleen, reduced cell cycling. . . | Gao et al., 1997 |
C57Bl/6 | Yes | A. fumigatus i.v. infection | Reduced survival, accelerated mortality | ||
C57Bl/6 | Yes | Granuloma formation (S. mansoni egg injection) | Reduced granuloma formation, excessive Th1 response | ||
Sv129 x C57Bl/6 | Yes | Nephrotoxic nephritis model | Increased renal injury, excessive Th1 response. | Topham et al., 1999 | |
Sv129 x C57Bl/6 | Yes | Leishmania infection | Less Th2 cytokine production, failure of parasite clearance. | Rodriguez-Sosa et al., 2003 | |
Balb/c (10 gen) | Yes | Pulmonary A. fumigatus infection | Reduced airway remodeling. | Blease et al., 2000 | |
Sv129 x C57Bl/6 | Yes | RSV infection | Reduced pathologic response and tissue damage. | Miller et al., 2006 | |
Sv129 x C57Bl/6 | Yes | Clostridium difficile toxin injection | Protective against enteritis. | Morteau et al., 2002 | |
Sv129 x C57Bl/6 | Yes | Cardiac allograft | Reduced graft rejection. | Gao et al., 2000; Hoshino et al., 2010 | |
C57Bl/6 | Yes | Analysis of bone formation | Fewer trabecular bones, impaired. osteoblast differentiation, defective osteoclastogenesis. | ||
CCR2 | Sv129 x C57Bl/6 | Yes | Thioglycollate peritonitis | Reduced macrophage recruitment; | Boring et al., 1997 |
Sv129 x C57Bl/6 | Yes | Granulomatous disease PPD of M. bovis | Reduced DTH and Th1 responses | ||
Sv129 x C57Bl/6 | Yes | Analysis of BM and spleen myeloid progenitor cell development | Enhanced progenitor cell cycling and increased apoptosis. | Reid et al., 1999 | |
Sv129 x C57Bl/6 | Yes | MOG-induced EAE | Pathology abrogated. | Fife et al., 2000 | |
Sv129 x ICR | Yes | L. monocytogenes infection | Failed bacterial clearance | Kurihara et al., 1997 | |
C57Bl/6 | DSS colitis | Protective. | Andres et al., 2000 | ||
Sv129 x C57Bl/6 | Yes | Inflammatory pain model (formalin and CFA) | Reduction of inflammatory pain response | Abbadie et al., 2003 | |
Sv129 x C57Bl/6 | Yes | Neuropathic pain (sciatic nerve ligation) | Abrogation of neuropathic pain response | ||
C57Bl/6 | West Nile Virus infection | . Absence of monocytosis, increased lethality of virus. | Lim et al., 2011 | ||
CCR3 | Balb/c | Yes | Analysis of eosinophil trafficking | Defective trafficking to intestinal mucosa | Humbles et al., 2002 |
Balb/c | Yes | OVA-induced skin inflammation | Defective eosinophil recruitment. | Ma et al., 2002 | |
Sv129 x C57Bl/6 | Yes | OVA-induced asthma model | Defective eosinophil recruitment. | Pope et al., 2005 | |
CCR4 | C57Bl/6 (4 gen) | Yes | OVA-induced airway inflammation; lethal endotoxemia | No effect; survival | Chvatchko et al., 2000 |
C57Bl/6 | Yes | Intraperitoneal Escherichia coli infection | Reduced bacterial numbers, enhanced PMN and monocyte recruitment | Ness et al., 2006 | |
C57Bl/6 | Yes | Polymicrobial sepsis model | Decreased mortality, enhanced bacterial clearance from organs. | Traeger et al., 2008 | |
C57Bl/6 | Yes | Dengue virus infection | Reduced lethality and tissue damage. | Guabiraba et al., 2010 | |
C57Bl/6 | Yes | A. fumigatus-induced inflammation | Reduced eosinophil recruitment and airway hyperresponsiveness. | Schuh et al., 2002b | |
CCR5 | Sv129 x ICR | Yes | L. monocytogenes infection | Reduced bacterial clearance | Zhou et al., 1998 |
Sv129 x ICR | Yes | Lethal endotoxemia | Survival | ||
Sv129 x ICR | Yes | DTH (FITC) model | Increased DTH reaction | ||
Sv129 x ICR | Yes | T-cell-dependent antigen challenge | Increased humoral response | ||
C57Bl/6 (8 gen) | Yes | MOG-induced EAE. | No effect | Tran et al., 2000 | |
Sv129 x C57Bl/6 | Yes | DSS colitis | Protective | Andres et al., 2000 | |
Sv129 x C57Bl/6 | Yes | Chronic fungal asthma. | Protective—disease transient | Schuh et al., 2002a | |
Sv129 x C57Bl/6 | Yes | Lymphocytic choriomeningitis virus infection model. | No effect | Nansen et al., 2002 | |
Sv129 x C57Bl/6 | Yes | Cryptococcus neoformans infection | Reduced survival, defective leukocyte recruitment to brain | Huffnagle et al., 1999 | |
Sv129 x C57Bl/6 | Yes | Graft versus host disease | Reduced survival, defective Treg recruitment | Wysocki et al., 2005 | |
C57Bl/6 | Yes | Paracoccidioides brasiliensis infection. | Smaller granulomas, better control of fungal growth, reduced Treg recruitment | Moreira et al., 2008 | |
CCR6 | Sv129 x C57Bl/6 | Yes | Cellular composition of MALT | Reduced DC numbers, altered T-cell populations in mucosa | Cook et al., 2000 |
Sv129 x C57Bl/6 | Yes | Oral antigen administration (KLH) | Reduced humoral response (fewer antibody-producing cells in mucosa) | ||
Sv129 x C57Bl/6 | Yes | Rotavirus infection | Reduced IgA response and viral clearance | ||
Sv129 x C57Bl/6 | Yes | Contact hypersensitivity. | More severe and persistent inflammation | Varona et al., 2001 | |
Sv129 x C57Bl/6 | Yes | DTH | No inflammatory response | ||
C57Bl/6 (8 gen) | Yes | DSS colitis | Protective | Varona et al., 2003 | |
C57Bl/6 (8 gen) | Yes | TNBS colitis in C57BL/6J mice | Confers susceptibility—- mice usually resistant. | ||
C57Bl/6 (8 gen) | Yes | Cockroach antigen pulmonary inflammation | Reduced airway resistance, eosinophil. recruitment and IL-5 production | Lukacs et al., 2001 | |
C57Bl/6 (8 gen) | Yes | MOG-induced EAE | Reduced disease score | Liston et al., 2009 | |
CCR7 | CD1 x Balb/c | LNs smaller | Analysis of cellular composition of blood and lymphoid organs | Increased Th cells in blood, bone marrow, and spleen; Reduced Th cells in LN and morphologic alterations in LN | Forster et al., 1999 |
CD1 x Balb/c | Spleens enlarged | Contact and delayed-type hypersensitivity | No response to antigen challenge | ||
C57Bl/6 and Balb/c | Analysis of lymphocyte development | Th2 polarization, increased IL-4 in LN, B cell activation | Moschovakis et al., 2012 | ||
CCR8 | Sv129 x C57Bl/6 | Yes | Granuloma formation (S. mansoni egg injection). | Impaired Th2 response, reduced eosinophil recruitment | Chensue et al., 2001 |
Sv129 x C57Bl/6 | Yes | Cockroach antigen pulmonary inflammation | Impaired Th2 response, reduced eosinophil recruitment | ||
Sv129 x C57Bl/6 | Yes | PPD of M. bovis injection | No effect, Th1 response normal | ||
C57Bl/6 (10 gen) | Yes | Analysis of monocyte trafficking (latex bead labeling) | Defective monocyte-derived DC trafficking to LN | Qu et al., 2004 | |
C57Bl/6 | Yes | Chronic fungal asthma | Protective, enhanced clearance of fungi | Buckland et al., 2007 | |
C57Bl/6 | Yes | Atopic dermatitis | Less eosinophilic inflammation, defective recruitment of Th2 cells to inflamed skin | Islam et al., 2011 | |
CCR9 | C57Bl/6 | Yes | Analysis of lymphocyte development | No major effect on T or B cell development | Wurbel et al., 2001 |
C57Bl/6 | Yes | Analysis of plasma cell localization | Defective recruitment of IgA-secreting cells into small intestine | Pabst et al., 2004 | |
C57Bl/6 | Yes | Oral antigen administration | Defective IgA response | ||
Sv129 x C57Bl/6 | Yes | Rotavirus infection | Normal recruitment of IgA+ plasmablasts to small intestine | Feng et al., 2006 | |
Sv129 x C57Bl/6 | Yes | ConA-induced hepatitis | Protected from hepatitis unless CCR9+ macrophages present | Nakamoto et al., 2012 | |
CCR10 | Balb/c (7 gen) | Yes | Analysis of IgA-secreting cells to mucosa | Defective recruitment of IgA-secreting cells to mammary gland | Morteau et al., 2008 |
C57Bl/6 (8 gen) | Yes | Analysis of γδ T-cell development. | Defective migration of skin intraepithelial Vδ3+ lymphocytes. | Jin et al., 2010b |