• DARPP-32 levels are increased in the striatum. |
• DARPP-32 abnormally phosphorylated at the Thr34 residue are increased in the striatum. |
• ERK1/2 phosphorylation is increased in the striatum. |
• Genetic inactivation of DARPP-32 attenuates the development of LI-AIMs in the 6-OHDA-lesioned mouse. |
• Blockade of the mitogen-activated kinase/ERK kinase with SL327 attenuates the development of LI-AIMs in the 6-OHDA-lesioned mouse. |
• Development of LI-AIMs is reduced in Ras-GRF1-knockout mice. |
• Striatal delivery of a dominant-negative construct of Ras-GRF1 attenuates the severity of established LID in the MPTP-lesioned macaque. |
• CalDAG-GEF1/2 levels are altered in the striatum of the dyskinetic 6-OHDA-lesioned rat killed in the off-state. |
• Histone H3 is dephosphorylated in the striatum of the dyskinetic MPTP-lesioned NHP. |
• Histone H4 is deacetylated in the striatum of both dyskinetic MPTP-lesioned NHPs and dyskinetic 6-OHDA-lesioned mice killed at peak LID. |