Representative studies showing relation between novelty seeking and drug reward
| Reference | Animal | Predictor Variable | Outcome Variable | Drug | Results |
|---|---|---|---|---|---|
| Stimulants | |||||
| Abreu-Villaca et al. (2006) | Female and male C57/BL/6 mice | Head dips in hole board | 2-Bottle choice | Nicotine (0.01 mg/ml p.o.) | HiNS > LoNS |
| Belin et al. (2011) | Male Sprague-Dawley rats | Novel place preference | SA on FR1 | Cocaine (0.8 mg/kg i.v.) | HiNS =LoNS (acquisition) HiNS > LoNS (compulsivity) |
| Cain, et al. (2005) | Male Sprague-Dawley rats | Novel place and novel object preference | SA on FR5 | Amphetamine (0.01–0.1 mg/kg i.v.) | HiNS > LoNS (regression Analysis) |
| Klebaur and Bardo (1999) | Male Sprague-Dawley rats | Novel object preference | CPP | Amphetamine (1–3 mg/kg s.c.) | HiNS > LoNS (1 mg/kg) |
| Klebaur et al. (2001a) | Female and male Sprague-Dawley rats | Novel place and novel object preference | SA on FR5 | Amphetamine (0.03–0.16 mg/kg i.v.) | HiNS =LoNS |
| Marusich et al. (2011) | Male Sprague-Dawley rats | Novel place preference | SA on FR5 and PR | Amphetamine (0.0056–0.1 mg/kg i.v.) | HiNS > LoNS (linear mixed model) |
| Pelloux et al. (2004) | Male Wistar rats | Novel place preference | CPP and SA | Amphetamine CPP (1.25–5 mg/kg i.p.) Amphetamine SA (10-50 mg/ml p.o.) | HiNS =LoNS (CPP) HiNS > LoNS (SA of 15 mg/ml) |
| Robinet et al. (1998) | Male Sprague-Dawley rats | Novel place preference | CPP | Amphetamine (0.4 mg/kg s.c.) | HiNS > LoNS |
| Vidal-Infer et al. (2012) | Female and male OF1 mice | Novel place preference | CPP | Cocaine (1 mg/kg i.p.) | HiNS > LoNS |
| Opiates | |||||
| Pelloux et al. (2006) | Male Wistar rats | Novel place preference | CPP and 2-bottle choice | Morphine CPP (1.25–5 mg/kg i.p.) Morphine 2-bottle (25-50 mg/ml p.o.) | HiNS > LoNS (CPP with 5 mg/kg) HiNS > LoNS (choice of 25 mg/ml) |
| Alcohol | |||||
| Bienkowski et al. (2001) | Male Wistar rats | Novel object preference | SA on FR1 | Alcohol (8% p.o.) | HiNS =LoNS |
HiNS, high novelty seeker; LoNS, low novelty seeker; SA, self-administration.