Representative studies showing relation between impulsivity and drug reward
| Reference | Animal | Predictor Variable | Outcome Variable | Drug | Results |
|---|---|---|---|---|---|
| Stimulants | |||||
| Anker et al. (2009) | Female Wister rats | Delay discounting | SA on FR1 and PR | Cocaine (0.2–0.8 mg/kg i.v.) | HiI > LoI (escalation) |
| Bird and Schenk (2012) | Male Sprague-Dawley rats | 5-CSRTT | SA on FR5 | MDMA (1.0 mg/kg i.v.) | HiI =LoI (acquisition) HiI > LoI(reinstatement) |
| Broos et al. (2012) | Male Wister rats | Delay discounting | SA on FR1 | Cocaine (0.015–0.5 mg/kg i.v.) | HiI > LoI (resistance to extinction) |
| Dalley et al. (2007) | Male Lister rats | 5-CSRTT | SA on FR1 | Cocaine (0.25 mg/kg i.v.) | HiI =LoI (acquisition) HiI > LoI (escalation) |
| Diergaarde et al. (2008) | Male Wistar rats | 5-CSRTT and delay discounting | SA on FR1-25 | Nicotine (0.04 mg/kg i.v.) | HiI > LoI w/ 5-CSRTT (acquisition) HiI > LoI w/ delay discounting (reinstatement) |
| Marusich and Bardo (2009) | Male Sprague-Dawley rats | Delay discounting | SA on FR5 | Methylphenidate (0.03–1.0 mg/kg i.v.) | HiI > LoI (maintenance of 0.1 mg/kg) |
| Marusich et al. (2011) | Male Sprague-Dawley rats | Delay discounting and cued go/no-go | SA on FR5 and PR | Amphetamine (0.0056–0.1 mg/kg i.v.) | HiI < LoI w/ delay discounting (linear mixed model) HiI =LoI w/ cued go/no-go |
| Perry et al. (2005) | Female Wistar rats | Delay discounting | SA on FR1 | Cocaine (0.2 mg/kg i.v.) | HiI > LoI (acquisition) |
| Perry et al. (2008) | Female and Male Wister rats | Delay discounting | SA on FR1 | Cocaine (0.2 mg/kg i.v.) | HiI > LoI (acquisition in female and male) (reinstatement in female) |
| Yates et al. (2012) | Male Sprague-Dawley rats | Delay discounting | CPP | Amphetamine (0.1-1.5 mg/kg s.c.) | HiI > LoI (0.5 and 1.5 mg/kg) |
| Opiates | |||||
| McNamara et al. (2010) | Male Lister rats | 5-CSRTT | SA on FR1 | Heroin (0.04 mg/kg i.v.) | HiI =LoI (acquisition and escalation) |
| Schippers et al. (2012) | Female Wistar rats | Delay discounting | SA on FR4 and PR | Heroin (0.1 mg/kg i.v.) | HiI =LoI |
| Alcohol | |||||
| Poulos et al. (1995) | Male N/NIH rats | Delay discounting | 2-Bottle choice | Alcohol (3%–12% p.o.) | HiI > LoI (maintenance of 12%) |
HiI, high impulsive; LoI, low impulsive; SA, self-administration.