TABLE 3

Pathologic conditions involving complement peptide C5a

Pathologic ConditionReference
Cardiovascular
 Fibrosis in hypertensionIyer et al., 2011
 Atherosclerosis in ApoE−/− miceManthey et al., 2011
 Preclinical atherosclerosis associated with systemic lupus erythematosusRua-Figueroa et al., 2010
 Arterial injury in atherosclerosis-prone miceShagdarsuren et al., 2010
 Hemodialysis-associated thrombosisKourtzelis et al., 2010
 Human coronary lesionsSpeidl et al., 2011
 Complement and coagulation cascadesOikonomopoulou et al., 2012
 Pancreatic islet cells express C5a1 receptor, C5a2 receptorTokodai et al., 2011
Arthritis
 Inflammation in autoimmune arthritisSong et al., 2011
 Inflammatory arthritisTsuboi et al., 2011
 Rheumatoid arthritisHueber et al., 2010
 Autoimmune arthritisHashimoto et al., 2010
Renal
 Kidney graft survivalLewis et al., 2008; Li et al., 2010
 Complement-induced tubulointerstitial injuryBao et al., 2011
Age-related macular degeneration
 T-cell cytokine release in AMDLiu et al., 2011a
Nervous system
 Cerebral arteriovenous malformationsHaque et al., 2011
 Incisional painJang et al., 2011
 Nociceptive sensitizationJang et al., 2010
 Mitochondrial functions of PC12 cellsMartinus and Cook, 2011
 Complement-
Toll-like receptor cross-talkWang et al., 2010; Raby et al., 2011
 Blood-brain barrier integrity in experimental lupusJacob et al., 2010c
 Alzheimer's diseaseAger et al., 2010
 Experimental autoimmune encephalomyelitisRamos et al., 2009
 Experimental CNS lupusJacob et al., 2010b
 Pituitary gland functionFrancis et al., 2008
 Amyotrophic lateral sclerosisWoodruff et al., 2008
Infection
 Experimental periodontitisBreivik et al., 2011
 Bone loss in P. gingivalis infectionLiang et al., 2011
 Necrotizing enterocolitisTayman et al., 2011
S. aureus bacteremiavon Köckritz-Blickwede et al., 2010
 Cerebral malariaPatel et al., 2008
 Gram-negative bacteremia and endotoxic shockHollmann et al., 2008
 NKT and NK function in sepsisFusakio et al., 2011
Respiratory disease
 Chronic obstructive pulmonary diseaseMarc et al., 2010
 Experimental allergic asthmaLajoie et al., 2010; Zhang et al., 2010
Other disease
 Bullous pemphigoidHeimbach et al., 2011
 Familial Mediterranean feverErken et al., 2010
Pregnancy
 Preterm deliveryGonzalez et al., 2011
Liver
 Fulminant hepatic liver failureSun et al., 2011
  • Further examples of C5a involvement in disease are detailed in Monk et al. (2007). CNS, central nervous system; NK, natural killer cell; NKT, natural killer T cell.