TABLE 2

Pathologic conditions involving complement peptide C3a

Pathologic ConditionReference
Cardiovascular
 Atherosclerotic coronary plaquesOksjoki et al., 2007
 Myocardial ischemia and reperfusion injuryBusche and Stahl, 2010
 Cardiometabolic riskOnat et al., 2011
 Resistant hypertensionMagen et al., 2010
 Spontaneous hypertensionXie et al., 2011a
Hepatic
 Hepatic function after steatotic liver transplantationXu et al., 2010b
Renal
 Renal ischemia/reperfusionThurman et al., 2007
 Proteinuric nephropathyTang et al., 2009
 Renal injury in the MRL/lpr mouseWenderfer et al., 2009
 β-Catenin in renal tubular cellsLiu et al., 2011b
 Complement-induced tubulointerstitial injuryBao et al., 2011
 Lupus nephritisMizuno et al., 2007
Infection
 Gram-negative bacteremia and endotoxic shockHollmann et al., 2008
P. aeruginosa -induced pneumoniaMueller-Ortiz et al., 2006
Arthritis
 Chemotactic activity in synovial fluidWard and Zvaifler, 1971
 Immune complex induced arthritisBanda et al., 2010
 Antigen-induced arthritisBanda et al., 2012
 Rheumatoid arthritisMoxley and Ruddy, 1985
 Juvenile-onset arthritisProkopec et al., 2012
 Antibody-induced arthritisHutamekalin et al., 2010
Nervous system
 Intracerebral hemorrhageGarrett et al., 2009
 Demyelination severityIngersoll et al., 2010
 Focal cerebral ischemiaMocco et al., 2006
 Nociceptive sensitizationJang et al., 2010
 Neurodegeneration in experimental lupusJacob et al., 2010a
 Brain injury after intracerebral hemorrhageRynkowski et al., 2009
 Granulocyte infiltration after focal cerebral ischemiaDucruet et al., 2008
Asthma
 Mucin expression by airway Clara cellsDillard et al., 2007
 Late asthmatic response and airway hyperresponsivenessMizutani et al., 2009
 Late-stage asthmaMizutani et al., 2012