TABLE 2
Compounds known to inhibit autophagy
| Type of Agents | Mechanism of Action | Compound | Structure |
|---|---|---|---|
| Inhibitor of class III PI3K | Inhibits the formation of autophagosome | 3-Methyladenine |  |
| Wortmannin |  | ||
| LY294002 |  | ||
| Inhibitor of the acidification of lysosome | Increases the pH and inhibits autophagosome-lysosome fusion and the digestive activity of lysosome | Bafilomycin A1 |  |
| Chloroquine |  | ||
| Inhibitor of the acidification of lysosome | Increases the pH and inhibits autophagosome-lysosome fusion and the digestive activity of lysosome | Hydroxychloroquine |  |
| Inhibitor of lysosomal proteolysis | Prevents the degradation of lysosome | Leupeptin |  |
| Pestatin A |  | ||
| Inhibitor of microtubule formation | Blocks the fusion of autophagosome with lysosome | Nocodazole |  |
| Colchicine |  | ||
| Vinblastine |  | ||
| Inhibitor protein transport | Blocks the fusion of the autophagosome and lysosome | Monensin |  |
| Inhibitor of ubiquitin-specific peptidases | Promotes the degradation of Vps34 complexes by enhancing Beclin1 ubiquitination | Spautin-1 |  |